82543-17-7

Basic information

• Product Name: (3S,5R,6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-octadecahydro-17-(3-hydroxy-1-propynyl)-10,13-dimethyl-5H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-3,5,17-triol
• Synonyms: (3S,5R,6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-octadecahydro-17-(3-hydroxy-1-propynyl)-10,13-dimethyl-5H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-3,5,17-triol;17-(3-Hydroxy-1-propynyl)-6,7:15,16-dimethyleneandrostane-3,5,17-triol
• CAS NO: 82543-17-7
• Molecular Formula: C₂₄H₃₄O₄
• Molecular Weight: 386.52436
• Product Categories: Chiral Reagents;Steroids
• Mol File: 82543-17-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Vapor Pressure: 0Pa at 25℃
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: (3S,5R,6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-octadecahydro-17-(3-hydroxy-1-propynyl)-10,13-dimethyl-5H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-3,5,17-triol(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5R,6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-octadecahydro-17-(3-hydroxy-1-propynyl)-10,13-dimethyl-5H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-3,5,17-triol(82543-17-7)
• EPA Substance Registry System: (3S,5R,6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-octadecahydro-17-(3-hydroxy-1-propynyl)-10,13-dimethyl-5H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-3,5,17-triol(82543-17-7)

Safety Data

• Hazardous Substances Data: 82543-17-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate for the preparation of Drospirenone.

Upstream product

• 107-19-7 propargyl alcohol 
• 82543-16-6 (2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR,9bR)-2,9b-dihydroxy-4a,6a-dimethyloctadecahydro-7H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-7-one 
• 67372-65-0 3β-hydorxy-15β,16β-methylene androst-5-ene-17-one 
• 82543-15-5 3β,5-dihydroxy-15β,16β-methylene-5β-androst-6-en-17-one 
• 82543-07-5 3β,7β-dihydroxy-15β,16β-methylene-5-androsten-17-one 
• 82543-14-4 5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one 
• 82544-13-6 5,6β-epoxy-7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one 
• 82543-13-3 7α-chloro-5,6β-epoxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one 
• 82543-09-7 7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5-androsten-17-one 
• 6175-54-8 hydroxy-1-propyne 

Downstream Products

• 82543-18-8 17α-(3-hydroxypropyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol 
• 90457-65-1 dihydrospirorenone 
• 74220-07-8 Spirorenone 
• 1079392-41-8 6β,7β;15β,16β-dimethylene-3β,5β-dihydroxy-17α-pregn-21,17-carbolactols 
• 197721-70-3 5β-hydroxy-3-carbonyl-6β,7β,5β,16β-dimethylene-17α-pregna-21,17-carboxylactone 

Relevant articles and documents

A drospirenone and intermediate preparation method (by machine translation)

The invention discloses a drospirenone and intermediate preparation method. Preparation method of this invention comprises the following steps: in the solvent, the compound 3 with hydrogen peroxide oxidation reaction shown below, to obtain compound 4 can be. Preparation method of this invention does not use a heavy metal reagent, reduces the toxicity of the preparation process, the use of the reagent are all conventional reagent, low cost, and is favorable for industrial large-scale production. (by machine translation)

Process for the preparation of drospirenone

A process is described for preparing drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for the preparation of pharmaceutical compositions with contraceptive action, starting from 5,6beta-epoxy-7beta-hydroxy-15beta,16beta-methylene-3beta-pivaloyloxy-5beta-androstan-17-one.

Synthese von Spirorenon, einem neuen stark wirksamen Aldosteron-Antagonisten

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