82572-04-1 Usage
General Description
-(+)-1-(1-naphthyl)ethylamine hydrochloride is a chemical compound with the molecular formula C12H13N · HCl. It is a salt form of the amine compound, 1-(1-naphthyl)ethylamine, and is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical products. It is also used as a reagent in organic chemistry for the preparation of a wide range of other compounds. The hydrochloride salt form of the compound is often more stable and easier to handle than the free base form, making it a preferred choice for many applications. Additionally, it is used as a precursor in the synthesis of various drugs, including antihistamines and antidepressants, due to its aromatic structure and amine functional group.
Check Digit Verification of cas no
The CAS Registry Mumber 82572-04-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,5,7 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 82572-04:
(7*8)+(6*2)+(5*5)+(4*7)+(3*2)+(2*0)+(1*4)=131
131 % 10 = 1
So 82572-04-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H13N.ClH/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11;/h2-9H,13H2,1H3;1H/t9-;/m1./s1
82572-04-1Relevant articles and documents
Efficient synthesis and practical resolution of 1-(naphthalen-1-yl) ethanamine, a key intermediate for cinacalcet
Mathad, Vijayavitthal T.,Shinde, Gorakshanath B.,Ippar, Sharad S.,Niphade, Navnath C.,Panchangam, Raghavendra K.,Vankawala, Pravinchandra J.
, p. 341 - 346 (2011/04/15)
An efficient synthesis of 1-(naphthalen-1-yl)ethanamine (RS-2) and its practical resolution to optically pure (1R)-(naphthalen-1-yl)ethanamine (R-(+)-2), a key intermediate in the synthesis of cinacalcet hydrochloride (1), is described. The resolution of RS-2 using R-(-)-mandelic acid as a resolving agent in ethanol was established on an industrial scale to give pure R-(+)-2 with >99.8% ee after liberation of the amine from its mandelate salt. An efficient process for the racemization of undesired isomer S-(-)-2 is also provided to maximize the yield of desired enantiomer.
