827-51-0

Basic information

• Product Name: Acetonitrile, (nitrosophenylamino)-
• CAS NO: 827-51-0
• Molecular Formula: C8H7N3O
• Molecular Weight: 161.163
• Mol File: 827-51-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetonitrile, (nitrosophenylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetonitrile, (nitrosophenylamino)-(827-51-0)
• EPA Substance Registry System: Acetonitrile, (nitrosophenylamino)-(827-51-0)

Safety Data

• Hazardous Substances Data: 827-51-0(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 98078-03-6 Phenylamino-acetonitrile; hydrochloride 
• 3009-97-0 N-phenylglycinonitrile 

Downstream Products

• 1008-78-2 5-amino-3-phenyl-1,2,3-oxadiazol-3-ium chloride 
• 132949-38-3 7,14-Diethyl-3,10-dimethyl-1,7,8,14-tetrahydro-1,3,5,7,8,10,12,14-octaaza-pentacene-2,4,9,11-tetraone 
• 108-95-2 phenol 
• 16155-51-4 α-Cyanomethyl-phenylhydrazin 
• 92875-90-6 oxalomonohydroximic acid-2-amid-1-anilide 
• 31180-71-9 acetyl(3-phenyl-1,2,3-oxadiazol-3-ium-5-yl)amide 
• 95493-12-2 6-benzoyl-3-phenylsydnoneimine 
• 114165-33-2 5-acetylamino-4-bromo-3-phenyl-[1,2,3]oxadiazolium betaine 
• 17572-02-0 5-nitrosoamino-3-phenyl-[1,2,3]oxadiazolium betaine 
• 90004-03-8 N-phenylcyanoformamidoxime 

Relevant articles and documents

Synthesis and pharmacological evaluation of 2,3-dialkylindoles, 'in vitro' inhibitors of thrombin-induced platelet aggregation

A series of 2,3-dialkylindoles (1-5) have been prepared and tested as antithrombotic agents. The whole class showed in vitro interesting activity in the inhibition of thrombin-induced aggregation. Among these compounds some ones showed activity comparable to standards also in the inhibition of collagen-induced aggregation. Owing to a very fast metabolic degradation through a beta-oxidative mechanism, a drastic decrease of activity in several tests ex vivo or in vivo was observed.

A Model for Metabolic Activation of Dialkylnitrosoamines. Oxidative Dealkylation 2-(N-Nitrosoalkylamino)acetonitriles by a Flavin Mimic in Aqueous Solution

It is found for the first time that a flavin mimic, benzodipteridine (BDP), reacts with 2-(N-nitrosoalkylamino)acetonitriles via oxidative dealkylation to yield the corresponding alcohols (ROH) and the 2-e-reduced BDP in aqueous acetonitrile.Kinetic studies reveal that the rates are first order with respect to and ->, respectively.Kinetic isotope effects (kH/kD) for RN(NO)CD2CN (R = Me, n-Bu, Ph, and PhCH2) are found to be 2.2-4.2, indicating that deprotonation is involved in the rate-determining step.The mechanism of the oxidative dealkylation of the nitrosoamines by the flavin mimic is discussed.