3009-97-0Relevant articles and documents
Dynamics in Catalytic Asymmetric Diastereoconvergent (3 + 2) Cycloadditions with Isomerizable Nitrones and α-Keto Ester Enolates
Adachi, Masaya,Akakabe, Mai,Ezawa, Tetsuya,Hashizume, Daisuke,Koshino, Hiroyuki,Sodeoka, Mikiko,Sohtome, Yoshihiro
supporting information, p. 9094 - 9104 (2021/07/01)
Reaction design in asymmetric catalysis has traditionally been predicated on a structurally robust scaffold in both substrates and catalysts, to reduce the number of possible diastereomeric transition states. Herein, we present the stereochemical dynamics in the Ni(II)-catalyzed diastereoconvergent (3 + 2) cycloadditions of isomerizable nitrile-conjugated nitrones with α-keto ester enolates. Even in the presence of multiple equilibrating species, the catalytic protocol displays a wide substrate scope to access a range of CN-containing building blocks bearing adjacent stereocenters with high enantio- and diastereoselectivities. Our computational investigations suggest that the enantioselectivity is governed in the deprotonation process to form (Z)-Ni-enolates, while the unique syn addition is mainly controlled by weak noncovalent bonding interactions between the nitrone and ligand.
Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules
Heidarian, Mahdi,Moghaddam, Firouz Matloubi,Pourkaveh, Raheleh
, (2020/11/03)
Oxidative cyanation of sp3C–H bonds at the α position of amines was achieved using CoCuFe2O4 as a catalyst and NaCN as an inexpensive cyanide source at room temperature. CoCuFe2O4 was found to be an active catalyst for Csp [3]-Csp coupling, efficiently delivering valuable α-aminonitriles from tertiary/secondary amines in good yields. The corresponding products were obtained with high selectivity toward α position. In addition, functional group tolerance offered the opportunity for application in late-stage functionalization of biologically active molecules. This transformation proceeds convenient on a gram-scale, and the catalyst can be reused for several runs with consistent catalytic activity.
A process for preparing aniline base second grade nitrile system and method
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Paragraph 0043-0046, (2019/05/28)
The invention relates to a method for preparing n-system and method. First, the invention provides an improved pipe-type continuous reaction system, the system through the flow or mass of material entering the system of the shunt to measure to control the material reaction, and the introduction of a new feeding mode and take with a mixing element of the reactor, so that the system can enhance the mass transfer of the reaction raw materials, the reaction efficiency is improved. In addition, the invention also provides a method for preparing n-method, the method utilizing the above-mentioned reaction system to realize, this method can reduce the hydroxy acetonitrile to aniline disubstituted formation of impurities, can also reduce the hydroxy acetonitrile in the alkaline catalyst under the influence of the polymerization, the product quality is improved and the reaction yield.
