827-88-3

Basic information

• Product Name: ALPHA-CYCLOPROPYL-4-FLUOROBENZYL ALCOHOL
• Synonyms: ALPHA-CYCLOPROPYL-4-FLUOROBENZYL ALCOHOL;CYCLOPROPYL(4-FLUOROPHENYL)METHANOL;alpha-Cyclopropyl-4-fluorobenzyl alcohol, 98+%;α-Cyclopropyl-4-fluorobenzylalcohol;α-Cyclopropyl-4-fluorobenzenemethanol
• CAS NO: 827-88-3
• Molecular Formula: C₁₀H₁₁FO
• Molecular Weight: 166.19
• EINECS: 212-576-2
• Mol File: 827-88-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 250.8°C at 760 mmHg
• Flash Point: 128.9°C
• Appearance: /
• Density: 1.13
• Vapor Pressure: 0.0111mmHg at 25°C
• Refractive Index: 1.517-1.519
• PKA: 14.22±0.20(Predicted)
• CAS DataBase Reference: ALPHA-CYCLOPROPYL-4-FLUOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-CYCLOPROPYL-4-FLUOROBENZYL ALCOHOL(827-88-3)
• EPA Substance Registry System: ALPHA-CYCLOPROPYL-4-FLUOROBENZYL ALCOHOL(827-88-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• Hazardous Substances Data: 827-88-3(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

InChI:InChI=1/C10H11FO/c11-9-5-3-8(4-6-9)10(12)7-1-2-7/h3-7,10,12H,1-2H2/t10-/m0/s1

Upstream product

• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 
• 462-06-6 fluorobenzene 
• 23719-80-4 cyclopropylmagnesium bromide 
• 459-57-4 4-fluorobenzaldehyde 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1489-69-6 Cyclopropanecarboxaldehyde 

Downstream Products

• 7515-48-2 (E)-1-(4-bromobut-1-en-1-yl)-4-fluorobenzene 
• 70250-64-5 (E)-1-(4-chlorobut-1-en-1-yl)-4-fluorobenzene 
• 536742-61-7 1-(4-fluorophenyl)pyrrolidin-3-ol 
• 618068-66-9 2-(2-azido-ethyl)-3-(4-fluoro-phenyl)-oxirane 
• 7515-50-6 (E)-4-(4-fluorophenyl)but-3-en-1-ol 
• 7515-49-3 trans-1-(4-Fluor-phenyl)--acetat 
• 7515-58-4 1-<4-Fluor-phenyl>--β-naphthylsulfonat 
• 298690-60-5 (+/-)-(S)-2-(4-fluorophenyl)-1-(toluene-4-sulfonyl)pyrrolidine 
• 1108697-86-4 N-[cyclopropyl(4-fluorophenyl)methyl]-4-methylbenzenesulfonamide 
• 1202770-27-1 3-[Cyclopropyl(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole 
• 1202770-79-3 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-5-fluoro-7-[(methylsulfonyl)methyl]-1H-indole 
• 709-44-4 (4-Fluor-phenyl)-cyclopropyl-carbinolmethylether 

Relevant articles and documents

CuBr2-catalyzed ring opening/formylation reaction of cyclopropyl carbinols with DMF to synthesize formate esters

An unprecedented protocol for the synthesis of formate esters has been developed by employing N,N-dimethylformamide (DMF) as both the source of CHO and solvent. This reaction undergoes ring opening of the cyclopropyl carbinols and in situ formation of homoallylic alcohols, which reacts with DMF to give the desired products. The substrate cyclopropyl carbinols with different groups participate smoothly in this process and the desired products are obtained in moderate to good yields.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE

Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

Amination of arenes through electron-deficient reaction cascades of aryl epoxyazides

(Matrix presented) Aryl epoxyazides undergo efficient electron-deficient reaction cascades mediated by Lewis acids, leading to regiospecific amination of the aromatic ring.