827340-35-2Relevant articles and documents
Total synthesis of calothrixins A and B via oxidative radical reaction of cyclohexenone with aminophenanthridinedione
Xu, Su,Nguyen, Thao,Pomilio, Irene,Vitale, Maria C.,Velu, Sadanandan E.
, p. 5928 - 5933 (2014)
Bioactive indolo[3,2-j]phenanthridine alkaloids, calothrixin B and its N-oxide derivative calothrixin A have been synthesized via an oxidative free radical reaction. Calothrixin B is generated from the commercially available 2,4,5-trimethoxybenzaldehyde in only seven steps. The key step in this synthesis is the Mn(OAc)3 mediated oxidative free radical reaction of 9-(benzylamino)phenanthridine-7,10-dione with cyclohexenone to form 12-benzyl-12H-indolo[3,2-j]phenanthridine-7,13-dione.
A General Carbazole Synthesis via Stitching of Indole-Ynones with Nitromethanes: Application to Total Synthesis of Carbazomycin A, Calothrixin B, and Staurosporinone
Singh, Shweta,Samineni, Ramesh,Pabbaraja, Srihari,Mehta, Goverdhan
, p. 3372 - 3376 (2019/05/10)
A new, one-pot domino benzannulation reaction between indole-3-ynones and various nitromethane derivatives has been explored for a general entry to diversely functionalized carbazole frameworks (28 examples). The scope of this new benzannulation has been
Total synthesis of calothrixin B via sequential Sonogashira coupling/copper-catalyzed oxidative cyclization
Ramkumar, Nagarajan,Nagarajan, Rajagopal
, p. 11046 - 11051 (2015/11/25)
A total synthesis of the antimalarial indolo[3,2-j]phenanthridine alkaloid calothrixin B is reported. The key intermediate, ketoester 11, was assembled using sequential Sonogashira coupling and intra/intermolecular fashioned copper-catalyzed oxidative cyclization reactions.
