82735-28-2

Basic information

• Product Name: 6-methoxy-3-(trichloromethyl)-2-benzofuran-1(3H)-one
• Synonyms: 1(3H)-isobenzofuranone, 6-methoxy-3-(trichloromethyl)-; 3- Trichloromethyl-6-Methoxyl-1(3H)- Isobenzofuranone
• CAS NO: 82735-28-2
• Molecular Formula: C₁₀H₇Cl₃O₃
• Molecular Weight: 281.5198
• Mol File: 82735-28-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 419.8°C at 760 mmHg
• Flash Point: 183.9°C
• Density: 1.555g/cm³
• Vapor Pressure: 2.95E-07mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 6-methoxy-3-(trichloromethyl)-2-benzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-3-(trichloromethyl)-2-benzofuran-1(3H)-one(82735-28-2)
• EPA Substance Registry System: 6-methoxy-3-(trichloromethyl)-2-benzofuran-1(3H)-one(82735-28-2)

Safety Data

• Hazardous Substances Data: 82735-28-2(Hazardous Substances Data)

Upstream product

• 302-17-0 chloral hydrate 
• 5368-81-0 methyl 3-methoxybenzoate 
• 10259-22-0 ethyl 3-methoxybenzoate 
• 586-38-9 3-Methoxybenzoic acid 
• 7664-93-9 sulfuric acid 
• 7781-98-8 ethyl-3-hydroxybenzoate 
• 591-31-1 3-methoxy-benzaldehyde 
• 75-87-6 chloral 

Downstream Products

• 103262-60-8 2-ethyl-5-methoxy-benzoic acid 
• 586415-11-4 2-(β,β-dichloroethenyl)-5-methoxybenzoic acid 
• 52962-25-1 2-(carboxymethyl)-5-methoxybenzoic acid 
• 586415-13-6 4-[2-(3,4-dihydro-7-methoxy-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]benzenesulfonamide 
• 52008-91-0 2-ethyl-5-hydroxy-benzoic acid 
• 4702-29-8 7-methoxy-1H-isochromene-1,3(4H)-dione 
• 1370022-17-5 (3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate 
• 1370022-14-2 C₁₇H₁₄O₅ 
• 1419828-72-0 7-methoxy-3-(4-methoxyphenyl)-2-(4-(2-morpholinoethoxy)phenyl)isoquinolin-1(2H)-one 
• 1419828-80-0 7-methoxy-3-(4-methoxyphenyl)-2-(4-(2-(diethylamino)ethoxy)phenyl)isoquinolin-1(2H)-one 
• 1419829-22-3 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one 
• 1419829-29-0 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one 
• 1419828-89-9 7-hydroxy-3-(4-hydroxyphenyl)-2-(4-(2-(dimethylamino)ethoxy)phenyl)isoquinolin-1(2H)-one 
• 1419829-05-2 7-hydroxy-3-(4-hydroxyphenyl)-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)isoquinolin-1(2H)-one 

Relevant articles and documents

Synthesis of 3-Ferrocenyl Isocoumarins

The derivatives of 3-ferrocenyl isocoumarin were synthesized by the condensation of substituted homothphalic anhydride with ferrocene using phosphoric acid or anhydrous aluminium chloride as cyclising agent. Substituted homophthalic acid did not condense with ferrocene so homophthalic acids were converted into their anhydride and then allowed to react with ferrocene in the presence of polyphosphoric acid or in the presence of anhydrous aluminium chloride using dichloromethane as the solvent to give 3-ferrocenyl isocoumarins. 7-Methoxy, 6-methyl, 5,7-dihydroxy, 6,7-dimethoxy and 5,7-dimethoxy derivatives of 3-ferrocenyl isocoumarin were synthesized. All the compounds were characterised by melting point determination, elemental and spectral analysis.

3-PHENYL-7-HYDROXY-ISOCOUMARINS AS MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) INHIBITORS

This invention relates to 3-phenyl-7-hydroxy-isocoumarin compounds which are MIF inhibitors, compositions comprising said inhibitors and methods for treating or preventing diseases associated with MIF.

ENANTIOSELECTIVE ORGANIC ANHYDRIDE REACTIONS

Disclosed herein is enantioselective synthetic method comprising reacting an enolisable C4-C50 organic anhydride with a second compound selected from the group consisting of an aldehyde, a ketone, an aldimine, a ketimine or a Michael Acceptor in the presence of a bifunctional organocatalyst. The reaction may find particular utility in the enantioselective synthesis of medicinally relevant heterocycles, such as dihydroisocoumarins and dihydroisoquinolinones.