82740-35-0

Basic information

• Product Name: (2E)-1-amino-3-[(4-methoxyphenyl)(methyl)amino]propan-2-one oxime
• CAS NO: 82740-35-0
• Molecular Formula: C₁₁H₁₇N₃O₂
• Molecular Weight: 223.2716
• Mol File: 82740-35-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 410.5°C at 760 mmHg
• Flash Point: 202.1°C
• Density: 1.14g/cm³
• Vapor Pressure: 1.78E-07mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: (2E)-1-amino-3-[(4-methoxyphenyl)(methyl)amino]propan-2-one oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-amino-3-[(4-methoxyphenyl)(methyl)amino]propan-2-one oxime(82740-35-0)
• EPA Substance Registry System: (2E)-1-amino-3-[(4-methoxyphenyl)(methyl)amino]propan-2-one oxime(82740-35-0)

Safety Data

• Hazardous Substances Data: 82740-35-0(Hazardous Substances Data)

Usage

Description

(2E)-1-amino-3-[(4-methoxyphenyl)(methyl)amino]propan-2-one oxime is a chemical compound with the molecular formula C11H16N2O2. It is an oxime derivative containing an amino group and a methoxyphenyl(methyl)amino group. (2E)-1-amino-3-[(4-methoxyphenyl)(methyl)amino]propan-2-one oxime has potential pharmaceutical applications due to its structural properties and may act as a ligand for targeting specific receptors or enzymes in biological systems. Its properties and potential uses may be further explored through research and development in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
(2E)-1-amino-3-[(4-methoxyphenyl)(methyl)amino]propan-2-one oxime is used as a pharmaceutical compound for its potential to target specific receptors or enzymes in biological systems. Its unique structural properties make it a promising candidate for the development of new drugs and therapies.
Used in Medicinal Chemistry Research:
(2E)-1-amino-3-[(4-methoxyphenyl)(methyl)amino]propan-2-one oxime is used as a subject of research in medicinal chemistry. Its properties and potential uses can be further explored through scientific studies and experiments, leading to advancements in drug discovery and development.

Upstream product

• 82585-46-4 2-{2-[(E)-Hydroxyimino]-3-[(4-methoxy-phenyl)-methyl-amino]-propyl}-isoindole-1,3-dione 

Downstream Products

• 82585-58-8 (6-Amino-4-{2-[(E)-hydroxyimino]-3-[(4-methoxy-phenyl)-methyl-amino]-propylamino}-5-nitro-pyridin-2-yl)-carbamic acid ethyl ester 
• 82585-90-8 (5-amino-3-[(4-methoxy-phenyl)-methyl-amino]-methyl-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl)-carbamic acid ethyl ester 

Relevant articles and documents

New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)

Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.