827598-29-8

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-(4-quinazolinyl)-, 1,1-dimethylethyl ester
• CAS NO: 827598-29-8
• Molecular Formula: C17H22N4O2
• Mol File: 827598-29-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-(4-quinazolinyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-(4-quinazolinyl)-, 1,1-dimethylethyl ester(827598-29-8)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-(4-quinazolinyl)-, 1,1-dimethylethyl ester(827598-29-8)

Safety Data

• Hazardous Substances Data: 827598-29-8(Hazardous Substances Data)

Usage

General Description

1-Piperazinecarboxylic acid, 4-(4-quinazolinyl)-, 1,1-dimethylethyl ester is a chemical compound with the molecular formula C20H22N4O2. It belongs to the class of organic compounds known as quinazolines, which are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring, and a pyrimidine ring system. The 1,1-dimethylethyl ester of 1-piperazinecarboxylic acid, 4-(4-quinazolinyl)- is an ester with a piperazinecarboxylic acid as the core structure. 1-Piperazinecarboxylic acid, 4-(4-quinazolinyl)-, 1,1-dimethylethyl ester may have potential biological activity and is used in pharmaceutical research and drug development. It is important to handle this chemical with care and to follow proper safety protocols when working with it.

Upstream product

• 5190-68-1 4-chloroquinazoline 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 209733-20-0 4-piperazinylquinazoline hydrochloride 
• 853681-18-2 4-(piperazin-1-yl)quinazoline dihydrochloride 
• 853680-25-8 [1-(4-chloro-2-methylbenzyl)-2-oxo-2-(4-quinazolin-4-yl-piperazin-1-yl)-ethyl]-carbamic acid tert-butyl ester 
• 853678-27-0 (2R)-2-amino-3-phenyl-1-(4-quinazolin-4-yl-piperazin-1-yl)-propan-1-one 
• 1417558-50-9 C₁₉H₁₉BrN₄O 
• 1417558-48-5 C₁₉H₂₀N₄O 
• 59215-41-7 1-(4-quinazolinyl)piperazine 
• 1417558-52-1 C₁₉H₂₀N₄O 

Relevant articles and documents

Alpha,beta-unsaturated ketone compound containing aromatic heterocycles and preparation method and application thereof

The invention provides an alpha,beta-unsaturated ketone compound containing aromatic heterocycles and a preparation method and an application thereof. The compound has strong anti-tumor activity, andhas a structure represented by the formula (I) defined in the specification.

Aminomethyl-containing piperazinone compound as well as preparation method and application thereof

The invention discloses an aminomethyl-containing piperazinone compound as well as a preparation method and application thereof. The compound has a structure shown as a general formula (I). The invention further provides the preparation method and the application of the compound. The compound disclosed by the invention has certain activity of inhibiting AKT1 kinase and activity of inhibiting the growth of PC-3 tumor cells, and is used for preparing an anti-tumor medicine. The formula I is shown in the description.

Molecular docking and synthesis of novel quinazoline analogues as inhibitors of transcription factors NF-κB activation and their anti-cancer activities

NF-kB is a transcription factor protein complex that can be found in almost all animal cell types and is a key player in some cancers and inflammatory responses. It can enhance the proliferation rate, reduce apoptosis, as well as creating more blood flow to ensure the survival of cancer, thus blocking the NF-kB pathway has potential therapeutic benefit. We designed a series of compounds based on a quinazoline scaffold pharmacophore model which may have high binding affinity with the p50 subunit of NF-kB. The compound series with phenyl substitution at the 2 position of the quinazoline proved to be more effective at inhibiting NF-kB function both theoretically and experimentally. These compounds also reduce the proliferation of numerous tumor cell lines and the mean GI50 for compound 2a is 2.88 μM against the NCI-60 cell line. At the same time, compound 2a can induce significant apoptosis in EKVX cell line at the concentration of 1 μM.