82857-40-7

Basic information

• Product Name: N-METHYL-GAMMA-(2-METHYLPHENOXY)BENZENEPROPANAMINE HYDROCHLORIDE
• Synonyms: N-METHYLGAMMA-(2-METHYLPHENOXY) BENZENENPROPANAMINE HCL;N-METHYL-GAMMA-(2-METHYLPHENOXY)BENZENEPROPANAMINE HYDROCHLORIDE;N-METHYL-GAMMA-(2-METHYLPHENOXY)BENZENEPROPANAMINE HCL;rac AtoMoxetine Hydrochloride;LY 135252;N-Methyl-3-(2-Methylphenoxy)-3-phenylpropylaMine Hydrochloride
• CAS NO: 82857-40-7
• Molecular Formula: C17H22ClNO
• Molecular Weight: 291.82
• Product Categories: Aromatics;Inhibitors;Pharmacetes & Fine Chemicalsuticals
• Mol File: 82857-40-7.mol
• Article Data: 29

Chemical Properties

• Melting Point: 124-126°C
• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-METHYL-GAMMA-(2-METHYLPHENOXY)BENZENEPROPANAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYL-GAMMA-(2-METHYLPHENOXY)BENZENEPROPANAMINE HYDROCHLORIDE(82857-40-7)
• EPA Substance Registry System: N-METHYL-GAMMA-(2-METHYLPHENOXY)BENZENEPROPANAMINE HYDROCHLORIDE(82857-40-7)

Safety Data

• Hazardous Substances Data: 82857-40-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Beige Solid

Uses

Rac Atomoxetine Hydrochloride is a compound active at novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases.

Upstream product

• 95-48-7 ortho-cresol 
• 115290-81-8 (R)-N-methyl-3-phenyl-3-hydroxypropylamine 
• 60960-88-5 N-methyl-3-phenylprop-2-en-1-amine 
• 95-52-3 2-Fluorotoluene 
• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 
• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 
• 936-59-4 3-chloropropiophenone 
• 872996-05-9 (S)-tomoxetine (S)-(+)-mandelate 
• 2538-50-3 β-Methylaminoethyl phenyl ketone hydrochloride 
• 42142-52-9 3-methylamino-1-phenylpropan-1-ol 
• 1027094-45-6 (R)-atomoxetine oxalate 
• 115290-79-4 (R)-3-(2-methylphenoxy)-3-phenylprop-1-yl methanesulfonate 
• 74-89-5 methylamine 
• 93982-97-9 C₂₄H₂₅NO₃ 

Relevant articles and documents

A convenient method for preparing enantiomerically pure norfluoxetine, fluoxetine and tomoxetine

A convenient synthesis for enantiomers of norfluoxetine, fluoxetine and tomoxetine is described. All final products were derived from a common intermediate, 3-phenyl-3-hydroxypropylamine.

Preparation method of atomoxetine hydrochloride

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of atomoxetine hydrochloride serving as a medicine for treating attention deficit hyperactivity. According to the invention, commercially available (E)-N-methyl-3-phenyl-2-propylene-1-amine is adopted as a starting material, and addition, substitution and salification are carried out so as to prepare atomoxetine hydrochloride. The preparation method provided by the invention is simple in preparation process, simple and convenient to operate, relatively high in yield and suitable for industrial production, and can provide sufficient bulk drugs for research and development of medicines.

Preparation method of atomoxetine hydrochloride

The invention relates to the field of medicine chemistry, and provides a preparation method of atomoxetine hydrochloride. N-methyl-3-hydroxyl-benzedrine is used as an initial raw material to take an aromatic nucleophilic substitution with o-fluorotoluene; then, through (S)-racemic ethyl mandelate resolution, salt is obtained, and the atomoxetine hydrochloride is obtained. In the route, the multistep reaction uses the continuous operation; reaction post treatment extraction and chiral resolution salt forming solvents use methyl tertiary butyl ether; during the post treatment, reduced pressure concentration operation and anhydrous sodium sulfate drying steps are not used; the operation is simple; the total yield reaches 20 to 25 percent; the purity is 99.5 percent or higher; the relevant quality standard is met. The process does not have the special reaction parameter and equipment requirements; the yield is high; byproducts are few; the post treatment is simple; the reaction yield is high; the method is suitable for industrialized production.