82938-49-6

Basic information

• Product Name: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-4-oxo-, phenylmethyl ester, (S)-
• CAS NO: 82938-49-6
• Molecular Formula: C17H25NO3Si
• Molecular Weight: 319.476
• Mol File: 82938-49-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-4-oxo-, phenylmethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-4-oxo-, phenylmethyl ester, (S)-(82938-49-6)
• EPA Substance Registry System: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-4-oxo-, phenylmethyl ester, (S)-(82938-49-6)

Safety Data

• Hazardous Substances Data: 82938-49-6(Hazardous Substances Data)

Upstream product

• 2886-33-1 dibenzyl L-aspartate toluene-4-sulphonate 
• 2791-79-9 dibenzyl L-aspartate 
• 72776-06-8 (L)-N-(trimethylsilyl)dibenzyl aspartate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 72776-05-7 (S)-benzyl 4-oxoazetidine-2-carboxylate 
• 130540-09-9 dibenzyl (S)-2-(tert-butyldimethylsilylamino)succinate 

Downstream Products

• 158419-31-9 menthyl N-<1-tert-butyldimethylsilyl-2-azetidinone-4-carboxy>glycinate 
• 82938-50-9 (4S)-N-tert-butyldimethylsilylazetidin-2-one-4-carboxylic acid 
• 193959-27-2 (2S,3S)-1-[2-(3-Benzyloxycarbonyl-phenyl)-acetyl]-3-(4-hydroxy-benzyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 
• 193959-26-1 (3S,4S)-3-[4-[(1,1-dimethylethyl)diphenylsilyloxy]phenylmethyl]-4-benzyloxycarbonylazetidin-2-one 
• 342624-75-3 (3S,4S)-4-benzyloxycarbonyl-1-[3'-(benzyloxycarbonyl)phenylacetate]-3-[4'-(tert-butyldiphenylsilyloxy)benzyl]-2-azetidionone 
• 193959-25-0 (3S,4S)-4-benzyloxycarbonyl-1-(tert-butyldimethylsilyl)-3-[4'-(tert-butyldiphenylsilyloxy)benzyl]-2-azetidinone 

Relevant articles and documents

OBTENTION D'UN α-AMINO ALDEHYDE PTIQUEMENT ACTIF EN SERIE β-LACTAME

Oxidation of a suitable protected L-aspartic acid derived azetdione gives rise to a chiral β-lactam carboxaldehyde without significant racemization.

The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain

The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1.8 blockers. Subsequent optimization allowed the identification of compound 9, PF-06305591, as a potent, highly selective blocker with an excellent preclinical in vitro ADME and safety profile.

Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders

The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.