83197-70-0Relevant articles and documents
Novel sulfonamide-based carbamates as selective inhibitors of bche
?těpánková, ?árka,Enriz, Ricardo D.,Garro, Adriana D.,Ho?ek, Jan,Imramovsky, Ale?,Jampílek, Josef,Jendrzejewska, Izabela,Magar, Pratibha,Parravicini, Oscar,Pauk, Karel,Svr?ková, Katarina
, (2021/09/04)
A series of 14 target benzyl [2-(arylsulfamoyl)-1-substituted-ethyl]carbamates was prepared by multi-step synthesis and characterized. All the final compounds were tested for their abil-ity to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase
Chiral pyrazole derivative and synthesis method thereof
-
Paragraph 0027; 0030-0031; 0040; 0043-0044; 0053; 0056-0057, (2020/06/20)
The invention belongs to the technical field of organic synthesis, and discloses a chiral pyrazole derivative and a synthesis method thereof. The chiral pyrazole derivative is (1-(4'-amino-5'-carbamoyl-1'-pyrazolyl)-(S)-2-propyl-benzyloxy amide. The synth
IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys
Sumi, Kengo,Inoue, Yoshihiro,Nishio, Masahiro,Naito, Yasuhito,Hosoya, Takamitsu,Suzuki, Masaaki,Hidaka, Hiroyoshi
, p. 831 - 834 (2014/02/14)
Rho-associated coiled coil-formed protein kinase (ROCK) inhibitors are under development as a new class of antiglaucoma agents. Based on the potent ROCK inhibitor H-1152, previously developed by us, we explored the possibility of related compounds as anti