83767-73-1

Basic information

• Product Name: Benzene, 1-[(bromomethyl)thio]-4-chloro-
• CAS NO: 83767-73-1
• Molecular Formula: C7H6BrClS
• Molecular Weight: 237.548
• Mol File: 83767-73-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(bromomethyl)thio]-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(bromomethyl)thio]-4-chloro-(83767-73-1)
• EPA Substance Registry System: Benzene, 1-[(bromomethyl)thio]-4-chloro-(83767-73-1)

Safety Data

• Hazardous Substances Data: 83767-73-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 106-54-7 p-Chlorothiophenol 
• 18803-44-6 sodium p-chlorothiophenolate 
• 130876-78-7 {(p-chloro-phenylthio)methyl}tricyclohexylstannane 
• 128-08-5 N-Bromosuccinimide 
• 112474-70-1 <(4-chlorophenylthio)methyl>trimethylsilane 

Downstream Products

• 83767-74-2 1-(4-chlorophenylthio)methoxy-3-trifluoromethylbenzene 
• 68360-45-2 (4-chloro-phenoxy)-(4-chloro-phenylsulfanyl)-methane 
• 1206189-04-9 (Z)-6-[2-((4-chlorophenyl)thio)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206189-03-8 (E)-6-[2-((4-chlorophenyl)thio)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 38325-81-4 1-bromomethylsulfinyl-4-chlorobenzene 
• 933-01-7 4-chloro-benzenesulfenyl chloride 
• 123958-50-9 4-acetoxy-2-butynyl 4-chlorophenylthiomethyl ether 
• 123958-60-1 4-(4-chlorophenylthio)methoxy-2-butyn-1-ol 
• 67207-21-0 p-chlorophenylsulfenyl bromide 
• 86998-03-0 1-chloro-2-(4-chlorophenylthio)cyclohexane 
• 215316-99-7 4-(4-Chloro-phenylsulfanylmethoxy)-biphenyl 
• 68360-43-0 p-Chlorphenylthiomethyl-p-tolylether 
• 57440-43-4 ((4-chlorophenyl)thio)methyl acetate 
• 68360-42-9 1-chloro-4-phenoxymethylsulfanyl-benzene 

Relevant articles and documents

An expeditious and efficient bromomethylation of thiols: Enabling bromomethyl sulfides as useful building blocks

A facile and highly efficient method for the bromomethylation of thiols, using paraformaldehyde and HBr/AcOH, has been developed, which advantageously minimizes the generation of highly toxic byproducts. The preparation of 22 structurally diverse α-bromomethyl sulfides illustrates the chemo-tolerant applicability while bromo-lithium exchange and functionalization sequences, free radical reductions, and additions of the title compounds demonstrate their synthetic utility.

Process to produce a protease inhibitor

Disclosed is a novel process and novel intermediates to prepare [R-(R*,R*)]-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide (XIX) which is a protease inhibitor useful in treating humans infected with the HIV virus.

Desilylative Pummerer-like Rearrangement of α-Trimethylsilyl-substituted Sulphoxides and Sulphides: Formation of α-Acyloxy and α-Halogeno Sulphides

α-Trimethylsilyl-substituted sulphoxides and sulphides undergo rearrangement with loss of the silyl group when treated respectively with trifluoroacetic anhydride and with N-halogenosuccinimide in the presence of trifluoroacetic acid, giving α-acyloxy sulphides and α-halogeno sulphides.