840501-15-7

Basic information

• Product Name: Benzenemethanol, 4-amino-2-fluoro- (9CI)
• Synonyms: Benzenemethanol, 4-amino-2-fluoro- (9CI);(4-aMino-2-fluorophenyl)Methanol
• CAS NO: 840501-15-7
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.1429232
• Product Categories: VARIOUSAMINE
• Mol File: 840501-15-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 286.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.286±0.06 g/cm3(Predicted)
• PKA: 13.88±0.10(Predicted)
• CAS DataBase Reference: Benzenemethanol, 4-amino-2-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-amino-2-fluoro- (9CI)(840501-15-7)
• EPA Substance Registry System: Benzenemethanol, 4-amino-2-fluoro- (9CI)(840501-15-7)

Safety Data

• Hazardous Substances Data: 840501-15-7(Hazardous Substances Data)

Usage

Chemical compound

Benzenemethanol, 4-amino-2-fluoro(9CI)

Chemical Abstracts Service (CAS) registry number

115799-50-9
Derivative of benzenemethanol with a fluoro substitution
Potential applications in pharmaceutical and chemical industries
Can be used as a building block in the synthesis of organic compounds
Subject of interest for researchers and manufacturers in organic chemistry and drug development industries

Upstream product

• 73792-08-2 methyl 4-amino-2-fluorobenzoate 
• 1427-07-2 2-fluoro-4-nitrotoluene 
• 403-24-7 2-fluoro-4-nitrobenzoic acid 
• 392-09-6 2-fluoro-4-nitro-benzoic acid methyl ester 
• 660432-43-9 (2-fluoro-4-nitrophenyl)methanol 
• 446-31-1 2-fluoro-4-aminobenzoic acid 

Downstream Products

• 840501-16-8 (3-fluoro-4-hydroxymethyl-phenyl)-carbamic acid benzyl ester 
• 232950-90-2 5-(S)-Acetamidomethyl-3-[4'-formyl-3'-fluorophenyl]oxazolidine-2-one 
• 840501-17-9 [4-(tert-butyl-dimethyl-silanyloxymethyl)-3-fluoro-phenyl]-carbamic acid benzyl ester 
• 1413913-06-0 1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one 
• 1413913-08-2 2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzaldehyde 
• 1413913-13-9 2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide 
• 1413913-01-5 2-cyano-3-(2-fluoro-4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)-N,N-dimethylacrylamide 
• 1402585-33-4 phenyl (3-fluoro-4-(hydroxymethyl)phenyl)carbamate 
• 1402585-34-5 C₁₃H₁₂F₄N₄O₂ 
• 1402581-32-1 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-methyl]-3-[3-fluoro-4-(hydroxymethyl)-phenyl]-urea 
• 1402581-33-2 1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea 
• 1402581-34-3 1-[[2-(2,3-dichlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea 
• 1402581-35-4 1-[[2-(3-chloro-2-methoxyphenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea 
• 1402581-36-5 1-[[2-(5-chloro-2-methoxyphenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea 

Relevant articles and documents

Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic

Paradoxically, some TRPV1 agonists are, at the organismal level, both nonpungent and clinically useful as topical analgesics. Here, we describe the scaled-up synthesis and characterization in mouse models of a novel, nonpungent vanilloid. Potent analgesic activity was observed in models of neuropathic pain, and the compound blocked capsaicin induced allodynia, showing dermal accumulation with little transdermal absorption. Finally, it displayed much weaker systemic toxicity compared to capsaicin and was negative in assays of genotoxicity.

Mechanistic Evaluation of Bioorthogonal Decaging with trans-Cyclooctene: The Effect of Fluorine Substituents on Aryl Azide Reactivity and Decaging from the 1,2,3-Triazoline

Bioorthogonal prodrug activation/decaging strategies need to be selective, rapid and release the drug from the masking group upon activation. The rates of the 1,3-dipolar cycloaddition between a trans-cyclooctene (TCO) and a series of fluorine-substituted

SUBSTITUTED PYRAZOLYL-BASED CARBOXAMIDE AND UREA DERIVATIVES BEARING A PHENYL MOIETY SUBSTITUTED WITH A CO-CONTAINING GROUP AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with a CO-containing group as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.