840501-17-9

Basic information

• Product Name: Carbamic acid, [4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-fluorophenyl]-, phenylmethyl ester
• CAS NO: 840501-17-9
• Molecular Formula: C21H28FNO3Si
• Molecular Weight: 389.542
• Mol File: 840501-17-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-fluorophenyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-fluorophenyl]-, phenylmethyl ester(840501-17-9)
• EPA Substance Registry System: Carbamic acid, [4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-fluorophenyl]-, phenylmethyl ester(840501-17-9)

Safety Data

• Hazardous Substances Data: 840501-17-9(Hazardous Substances Data)

Upstream product

• 840501-15-7 (4-amino-2-fluorophenyl)methanol 
• 73792-08-2 methyl 4-amino-2-fluorobenzoate 
• 392-09-6 2-fluoro-4-nitro-benzoic acid methyl ester 
• 403-24-7 2-fluoro-4-nitrobenzoic acid 
• 1427-07-2 2-fluoro-4-nitrotoluene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 840501-16-8 (3-fluoro-4-hydroxymethyl-phenyl)-carbamic acid benzyl ester 

Downstream Products

• 232950-90-2 5-(S)-Acetamidomethyl-3-[4'-formyl-3'-fluorophenyl]oxazolidine-2-one 

Relevant articles and documents

Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones

Some novel oxazolidinone derivatives have been synthesized and tested for antibacterial activity. Compound 13 was found to be active against Gram-positive pathogens whereas compound 14 was less active. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. However, thioacetamide analogue of 13 produced a potent molecule similar to linezolid in vitro. Some novel oxazolidinone derivatives with benzotriazole as pendant have been synthesized and tested for antibacterial activity. Linearly attached benzotriazole derivative showed more potency compared to angular one in vitro. Out of E/Z-isomers of angularly attached derivatives E-isomer was found to be more potent than Z-isomer. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. Finally, thioacetamide analogue of linear compound gave a lead having activity similar to linezolid in vitro.