84299-48-9

Basic information

• Product Name: 2-bromo-4-phenyl-butyryl chloride
• Synonyms: 2-bromo-4-phenyl-butyryl chloride
• CAS NO: 84299-48-9
• Molecular Weight: 261.546
• Mol File: 84299-48-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-bromo-4-phenyl-butyryl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-phenyl-butyryl chloride(84299-48-9)
• EPA Substance Registry System: 2-bromo-4-phenyl-butyryl chloride(84299-48-9)

Safety Data

• Hazardous Substances Data: 84299-48-9(Hazardous Substances Data)

Upstream product

• 18496-54-3 phenylbutyric acid chloride 
• 16503-46-1 2-bromo-4-phenyl butanoic acid 
• 1821-12-1 4-Phenylbutyric acid 

Downstream Products

• 16503-47-2 2-bromo-4-phenyl-butyric acid methyl ester 

Relevant articles and documents

Enantioconvergent Cu-Catalyzed Radical C-N Coupling of Racemic Secondary Alkyl Halides to Access α-Chiral Primary Amines

α-Chiral alkyl primary amines are virtually universal synthetic precursors for all other α-chiral N-containing compounds ubiquitous in biological, pharmaceutical, and material sciences. The enantioselective amination of common alkyl halides with ammonia is appealing for potential rapid access to α-chiral primary amines, but has hitherto remained rare due to the multifaceted difficulties in using ammonia and the underdeveloped C(sp3)-N coupling. Here we demonstrate sulfoximines as excellent ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides (>60 examples) by copper catalysis under mild thermal conditions. The reaction efficiently provides highly enantioenrichedN-alkyl sulfoximines (up to 99% yield and >99% ee) featuring secondary benzyl, propargyl, α-carbonyl alkyl, and α-cyano alkyl stereocenters. In addition, we have converted the masked α-chiral primary amines thus obtained to various synthetic building blocks, ligands, and drugs possessing α-chiral N-functionalities, such as carbamate, carboxylamide, secondary and tertiary amine, and oxazoline, with commonly seen α-substitution patterns. These results shine light on the potential of enantioconvergent radical cross-coupling as a general chiral carbon-heteroatom formation strategy.

Privileged structure based ligands for melanocortin receptors - Substituted benzylic piperazine derivatives

Replacement of the aryl piperazine moiety in compound 1 with a variety of substituted benzylic piperazines (6) yields compounds that afford melanocortin receptor 4 (MCR4) activity. Analogs with ortho substitution on the aromatic ring afforded the highest