844501-71-9

Basic information

• Product Name: 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE
• Synonyms: 3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-PYRAZOLE;3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE-2-YL)PYRRAZOLE;3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE;3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOLONE)-PYRAZOLE;3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOLONE)-PYRRAZOLE;1H-Pyrazole-5-boronic acid pinacol ester;1H-Pyrazole-3-boronic acid pinacol ester, 95%;PYRAZOLE-3-BORONIC ACID PINACOL ESTER
• CAS NO: 844501-71-9
• Molecular Formula: C₉H₁₅BN₂O₂
• Molecular Weight: 194.04
• Mol File: 844501-71-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 105-108°C
• Boiling Point: 335.373 °C at 760 mmHg
• Flash Point: 156.628 °C
• Appearance: /
• Density: 1.091 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.02±0.10(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE(844501-71-9)
• EPA Substance Registry System: 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE(844501-71-9)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 45-37-26
• RIDADR: UN2811
• Hazardous Substances Data: 844501-71-9(Hazardous Substances Data)

Usage

Description

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolane)-pyrazole, also known as 1H-Pyrazol-3-ylboronic Acid Pinacol Ester, is a synthetic intermediate with a unique chemical structure that features a pyrazole ring and a boron-containing pinacol ester group. 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE is known for its potential applications in the synthesis of various organic compounds and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolane)-pyrazole is used as a synthetic intermediate for the preparation of (aminoaryl)(benzyloxy)pyridines, which are potential antitumor agents. These compounds have the potential to target and inhibit the growth of cancer cells, making them valuable in the development of new cancer treatments.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolane)-pyrazole serves as a versatile building block for the synthesis of a wide range of organic compounds. Its unique structure allows for various chemical reactions, enabling the creation of new molecules with diverse properties and potential applications.
Used in Material Science:
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolane)-pyrazole may also find applications in material science, particularly in the development of new materials with specific properties. Its ability to participate in various chemical reactions can contribute to the creation of novel materials with potential uses in various industries, such as electronics, energy, and environmental protection.

InChI:InChI=1/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-6-11-12-7/h5-6H,1-4H3,(H,11,12)

Downstream Products

• 1605329-05-2 (S)-2-(1-((5-(1H-pyrazol-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 
• 1459257-99-8 3-(4-(1H-pyrazol-3-yl)pyridin-2-yl)-N-isopropyl-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-4-amine 
• 59843-55-9 3-(2'-chlorophenyl)-1H-pyrazole 
• 1020174-04-2 1-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 
• 847818-74-0 1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 
• 1146162-54-0 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole 
• 133560-57-3 1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole 
• 1331786-30-1 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1H-pyrazol-5-yl)pyridin-2-amine