84467-54-9

Basic information

• Product Name: (+/-)-DIDESMETHYLSIBUTRAMINE
• Synonyms: 1-(1-(4-CHLOROPHENYL)CYCLOBUTYL)-3-METHYLBUTAN-1-AMINE;1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE;1-[1-(4-CHLOROPYENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE;CYCLOBUTANEMETHANAMINE, [1-(4-CHLOROPHENYL) ]-A-(2-METHYLPROPYL);1-[1-(4-Chlorophenyl)]-Alpha-(2-Methylpropyl)CyclobutaneMethanamine;l-(4-Chloro Phenyl)-a-(2-Methyl Propyl)-Cyclobutane Methanamine;[1-(4-chlorophenyl)]-alpha-(2-methylpropyl);Cyclobutanemethanamine
• CAS NO: 84467-54-9
• Molecular Formula: C15H22ClN
• Molecular Weight: 251.79
• Product Categories: Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Amines;Aromatics
• Mol File: 84467-54-9.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 337.9°C at 760 mmHg
• Flash Point: 195.1°C
• Appearance: /
• Density: 1.072g/cm³
• Vapor Pressure: 0.000102mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 10.82±0.42(Predicted)
• CAS DataBase Reference: (+/-)-DIDESMETHYLSIBUTRAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-DIDESMETHYLSIBUTRAMINE(84467-54-9)
• EPA Substance Registry System: (+/-)-DIDESMETHYLSIBUTRAMINE(84467-54-9)

Safety Data

• Hazardous Substances Data: 84467-54-9(Hazardous Substances Data)

Usage

Description

(+/-)-DIDESMETHYLSIBUTRAMINE is a metabolite of Sibutramine, a serotonin and noradrenaline reuptake inhibitor (SNR). It is a colorless oil with the ability to decrease calorie intake and increase energy expenditure.

Uses

Used in Pharmaceutical Industry:
(+/-)-DIDESMETHYLSIBUTRAMINE is used as an appetite suppressant for weight loss management. It functions by decreasing calorie intake and increasing energy expenditure, making it a potential candidate for obesity treatment and weight management programs.
Used in Research and Development:
(+/-)-DIDESMETHYLSIBUTRAMINE is used as a research compound to study the effects of serotonin and noradrenaline reuptake inhibition on appetite regulation and energy metabolism. This helps in understanding the underlying mechanisms of weight loss and the development of new therapeutic agents for obesity and related metabolic disorders.

InChI:InChI=1/C15H22ClN/c1-11(2)10-14(17)15(8-3-9-15)12-4-6-13(16)7-5-12/h4-7,11,14H,3,8-10,17H2,1-2H3

Upstream product

• 78-77-3 Isobutyl bromide 
• 28049-61-8 1-(4-chlorophenyl)cyclobutanecarbonitrile 
• 84467-85-6 N-{1-[1-(4-chlorophenylcyclobutyl)]-3-methylbuty}formamide 
• 421558-88-5 1-[1-(4-chloro-phenyl)-cyclobutyl]-3-methyl-butylideneamine 
• 140-53-4 p-chlorobenzyl cyanide 
• 926-62-5 isobutylmagnesium bromide 
• 259729-92-5 didesmethylsibutramine (D)-tartrate 
• 14377-68-5 1-phenylcyclobutanecarbonitrile 
• 186521-85-7 1-[1-(4-chloro-phenyl)cyclobutyl]-3-methyl-butan-1-one 
• 920-36-5 (2-methylpropyl)lithium 
• 858645-29-1 (R)-N-(1-(4-chlorophenyl)cyclobutanemethylene)-t-butanesulfinamide 
• 106079-12-3 1-(4-chlorophenyl)-cyclobutanecarboxaldehyde 
• 473554-13-1 (2S,4R,5S)-N-tosyl-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide 

Downstream Products

• 84467-85-6 N-{1-[1-(4-chlorophenylcyclobutyl)]-3-methylbuty}formamide 
• 259729-93-6 (R)-DDMS-D-TA 
• 154752-44-0 (R)-(+)-N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine 
• 229639-57-0 (S)-(-)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine 

Relevant articles and documents

COMPOSITIONS, SYNTHESIS, AND METHODS OF USING PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES

The present invention provides novel phenylcycloalkylmethylamme derivatives, and methods of preparing phenylcycloalkylmethylamme derivatives. The present invention also provides methods of using phenylcycloalkylmethylamme derivatives and compositions of phenylcycloalkylmethylamme derivatives. The pharmaceutical compositions of the compounds of the present invention can be used for treating and/or preventing obesity and obesity related co- morbid indications and depression and depression related co-morbid indications.

PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF

Phenylcyclobutylamide derivatives and their optical isomers, the preparing processes and the uses thereof, which includes the compounds of formula (I), their pure stereoisomers and their pharmaceutically acceptable salts. In formula (I), R is H, formacyl,

Highly enantioselective catalytic asymmetric synthesis of a (R)-sibutramin precursor

The first highly enantioselective, catalytic asymmetric synthesis of di-des-methylsibutramine 3 is described. Dienamide 10, prepared by acetic acid anhydride quenching of the condensation product of nitrile 4 with a methallyl magnesium chloride, proved to