845300-63-2Relevant articles and documents
A new class of non-racemic chiral macrocycles: A conformational and synthetic study
Gibson, Susan E.,Mainolfi, Nello,Kalindjian, S. Barret,Wright, Paul T.,White, Andrew J. P.
, p. 69 - 80 (2007/10/03)
Amino alcohols have been used to introduce non-racemic chirality into macrocycles using a modular approach that relies on a Heck macrocyclisation reaction. A wide variety of macrocycles have been synthesised, and their structures studied using X-ray crystallography and molecular modelling. A fragmentation reaction encountered during the use of (S)-1,1-dimethylvalinol revealed that carboxylic acids generate acylals under reaction conditions often used for Heck reactions.