845300-65-4

Basic information

• Product Name: 2-Pentanol, 3-[[(4-iodophenyl)methyl](phenylmethyl)amino]-2,4-dimethyl-, (3S)-
• CAS NO: 845300-65-4
• Molecular Formula: C21H28INO
• Molecular Weight: 437.364
• Mol File: 845300-65-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Pentanol, 3-[[(4-iodophenyl)methyl](phenylmethyl)amino]-2,4-dimethyl-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pentanol, 3-[[(4-iodophenyl)methyl](phenylmethyl)amino]-2,4-dimethyl-, (3S)-(845300-65-4)
• EPA Substance Registry System: 2-Pentanol, 3-[[(4-iodophenyl)methyl](phenylmethyl)amino]-2,4-dimethyl-, (3S)-(845300-65-4)

Safety Data

• Hazardous Substances Data: 845300-65-4(Hazardous Substances Data)

Upstream product

• 845300-63-2 (S)-3-(4-Iodo-benzylamino)-2,4-dimethyl-pentan-2-ol 
• 100-39-0 benzyl bromide 
• 619-58-9 4-iodobenzoic acid 
• 163453-95-0 (S)-3-amino-2,4-dimethylpentan-2-ol 
• 157035-77-3 tert-butyl (S)-(2-hydroxy-2,4-dimethylpentan-3-yl)carbamate 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 6306-52-1 L-valine methylester hydrochloride 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 18282-51-4 4-iodo-benzyl alcohol 

Relevant articles and documents

A new class of non-racemic chiral macrocycles: A conformational and synthetic study

Amino alcohols have been used to introduce non-racemic chirality into macrocycles using a modular approach that relies on a Heck macrocyclisation reaction. A wide variety of macrocycles have been synthesised, and their structures studied using X-ray crystallography and molecular modelling. A fragmentation reaction encountered during the use of (S)-1,1-dimethylvalinol revealed that carboxylic acids generate acylals under reaction conditions often used for Heck reactions.