84750-93-6

Basic information

• Product Name: 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE
• Synonyms: 1-bromo-4-(2,2-difluoroethenyl)-benzene;4-Bromo-β-difluorostyrene (stabilized with TBC);2-(4-BROMOPHENYL)-1,1-DIFLUOROETHYLENE;1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE;4-BROMO-BETA,BETA-DIFLUOROSTYRENE;4-Bromo-β,β-difluorostyrene (stabilized with TBC);4-Bromo-beta,beta-difluorostyrene (stabilized with TBC)
• CAS NO: 84750-93-6
• Molecular Formula: C₈H₅BrF₂
• Molecular Weight: 219.03
• Mol File: 84750-93-6.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 209.8°C at 760 mmHg
• Flash Point: 80.7°C
• Appearance: /
• Density: 1.57
• Vapor Pressure: 0.287mmHg at 25°C
• Refractive Index: 1.5420-1.5460
• Storage Temp.: Freezer
• CAS DataBase Reference: 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE(84750-93-6)
• EPA Substance Registry System: 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE(84750-93-6)

Safety Data

• Hazardous Substances Data: 84750-93-6(Hazardous Substances Data)

Usage

General Description

1-Bromo-4-(2,2-difluorovinyl)benzene is a chemical compound with the molecular formula C8H5BrF2. It is an organic compound that contains a benzene ring with a bromine atom and a difluorovinyl group attached. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE is a colorless liquid with a strong, sweet odor, and it is considered to be hazardous if ingested or inhaled. It is important to handle 1-Bromo-4-(2,2-difluorovinyl)benzene with caution and in a well-ventilated area to avoid any potential health risks.

InChI:InChI=1/C8H5BrF2/c9-7-3-1-6(2-4-7)5-8(10)11/h1-5H

Upstream product

• 19740-19-3 chlorodifluoroacetic acid lithium salt 
• 1122-91-4 4-bromo-benzaldehyde 
• 75-61-6 dibromodifluoromethane 
• 57477-93-7 hydrazone of p-bromobenzaldehyde 
• 895164-12-2 methanesulfonic acid 2-benzenesulfonyl-1-(4-bromo-phenyl)-2,2-difluoro-ethyl ester 
• 895164-05-3 1-(4-bromophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethan-1-ol 
• 1895-39-2 sodium chlorodifluoroacetate 
• 1219454-89-3 2-((difluoromethyl)sulfonyl)pyridine 
• 1258013-09-0 1-bromo-4-(2,2-difluoro-2-(phenylsulfonyl)ethyl)benzene 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 120801-75-4 trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate 
• 75-45-6 Chlorodifluoromethane 
• 1600503-70-5 potassium 2-pyridinyl sulfonyl-difluoroacetate 
• 115262-00-5 [chloro(difluoro)methyl]trimethylsilane 

Downstream Products

• 155820-88-5 1-bromo-4-(2,2,2-trifluoroethyl)benzene 
• 42122-27-0 (4-bromophenyl)-propynoic acid methyl ester 
• 1381980-30-8 1-benzyl-4-(4-bromophenyl)-3,3-difluoropyrrolidine 
• 1379771-31-9 2-(4-bromobenzyl)quinoline 
• 1501969-09-0 4,4'-((2RS,3SR)-1,1,1,4,4,4-hexafluorobutane-2,3-diyl)bis(bromobenzene) 
• 1589050-70-3 (E)-1-(2-(4-bromophenyl)-1-fluorovinyl)-1H-benzo[d]imidazole 
• 1589050-76-9 (Z)-1-(2-(4-bromophenyl)-1-fluorovinyl)-1H-benzo[d]imidazole 

Relevant articles and documents

Stereoselective formation of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem?difluoroalkenes with lithium organoborates

A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem?difluoroalkenes in mild conditions was described. The combination of lithium organoborate and ZnBr2 generated in situ lithium ar

Fluoride-Triggered Synthesis of 1-Aryl-2,2-difluoroalkenes via Desilylative Defluorination of (1-Aryl)-2,2,2-trifluoroethyl-silanes

An efficient route for the synthesis of 1-aryl-2,2-difluoroalkenes via 1,2-desilylative defluorination is disclosed. Only a catalytic amount of fluoride source is required to initiate the desilylation and afford gem-difluoroalkenes in very good to quantitative yields, using mild reaction conditions in dimethyl carbonate as a green solvent. This reaction uses (1-aryl)-2,2,2-trifluoroethyl-silanes, which are easily prepared via the insertion reaction of trifluoroethyl diazo alkanes into the Si-H bond of tertiary organosilanes. (1-Aryl)-perfluoroalkyl-silanes cleanly afford the corresponding (Z)-1-benzylideneperfluoroalkanes, which upon hydrodefluorination furnish the (E)-β(perfluoroalkyl)styrene derivatives with excellent yield and complete stereoselectivity. A one-pot system involving sequential insertion and desilylative-defluorination is also suitable for this transformation. This method demonstrates the usefulness of organosilanes toward the preparation of fluorinated alkenes as synthetically useful targets.

-Annulation of gem-Difluoroalkenes and Pyridinium Ylides: Access to Functionalized 2-Fluoroindolizines

A [3 + 2]-annulation of gem-difluoroalkenes and pyridinium ylides was developed employing ambient air as the sole oxidant in an open-vessel manner, affording a series of multifunctionalized 2-fluoroindolizines in moderate to good yields. In this reaction, gem-difluoroalkene acts as a C2 synthon and entirely avoids the competitive addition-elimination process, which provides facile access to 2-fluoroindolizines.