1219454-89-3 Usage
Description
Pyridine, 2-[(difluoromethyl)sulfonyl]-, also known as Difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H), is a chemical reagent with significant applications in organic synthesis. It is characterized by its ability to facilitate gem-difluoroolefination reactions and serves as a crucial intermediate in the formation of 1,1-difluorinated alkyl chains.
Uses
Used in Organic Synthesis:
Pyridine, 2-[(difluoromethyl)sulfonyl]is used as a gem-difluoroolefination reagent for both aldehydes and ketones under basic conditions. This application is particularly valuable in the synthesis of gem-difluoro olefins, which are important building blocks in the development of various pharmaceuticals and agrochemicals.
Used in the Synthesis of 1,1-Difluorinated Alkyl Chains:
The reagent is also used as a crucial intermediate in the formation of 1,1-difluorinated alkyl chains, which are essential for the alkylation of heterocycles. This application highlights the versatility of Pyridine, 2-[(difluoromethyl)sulfonyl]in organic chemistry and its potential in creating novel molecular structures with unique properties.
Used in Nucleophilic Difluoro(Sulfonato)methylation:
Additionally, Pyridine, 2-[(difluoromethyl)sulfonyl]is employed as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides. This reaction provides a convenient method for the introduction of difluoromethyl groups into various organic substrates, further expanding the utility of this reagent in synthetic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1219454-89-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,9,4,5 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1219454-89:
(9*1)+(8*2)+(7*1)+(6*9)+(5*4)+(4*5)+(3*4)+(2*8)+(1*9)=163
163 % 10 = 3
So 1219454-89-3 is a valid CAS Registry Number.
1219454-89-3Relevant articles and documents
Direct synthesis of fluorinated heteroarylether bioisosteres
Zhou, Qianghui,Ruffoni, Alessandro,Gianatassio, Ryan,Fujiwara, Yuta,Sella, Eran,Shabat, Doron,Baran, Phil S.
, p. 3949 - 3952 (2013)
(Bioiso)steering in a new direction: A modular synthesis of reagents (e.g. sodium difluoroethylsulfinate) that can be used for the direct incorporation of difluoroalkyl groups onto heterocycles is reported. The scope and generality of the incorporation of
Modified Julia olefination on sugar-derived lactones: Synthesis of difluoro exo-glycals
Habib, Samuel,Gueyrard, David
, p. 871 - 875 (2015/01/30)
We report the preparation of difluoro-exo-glycals by gem-difluoroolefination of benzylated sugar-derived lactones using a modified Julia reaction. The addition is highly stereo-selective, and the Smiles-rearrangement-elimination sequence can be carried out under microwave irradiation.
Difluoromethyl 2-pyridyl sulfone: A new gem-difluoroolefination reagent for aldehydes and ketones
Zhao, Yanchuan,Huang, Weizhou,Zhu, Lingui,Hu, Jinbo
supporting information; experimental part, p. 1444 - 1447 (2010/06/20)
Chemical equation presented Difluoromethyl 2-pyridyl sulfone, a previously unknown compound, was found to act as a novel and efficient gem-difluoroolefination reagent for both aldehydes and ketones. It was found that the fluorinated sulfinate intermediate in the reaction is relatively stable, which can be observed by 19F NMR and trapped with CH 3l.
