847585-91-5

Basic information

• Product Name: 2-Naphthalenecarboxaldehyde, 3,4-dihydro-1-methyl-6-(phenylmethoxy)-
• CAS NO: 847585-91-5
• Molecular Formula: C19H18O2
• Molecular Weight: 278.351
• Mol File: 847585-91-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Naphthalenecarboxaldehyde, 3,4-dihydro-1-methyl-6-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenecarboxaldehyde, 3,4-dihydro-1-methyl-6-(phenylmethoxy)-(847585-91-5)
• EPA Substance Registry System: 2-Naphthalenecarboxaldehyde, 3,4-dihydro-1-methyl-6-(phenylmethoxy)-(847585-91-5)

Safety Data

• Hazardous Substances Data: 847585-91-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 32263-70-0 6-benzyloxy-3,4-dihydro-2H-naphthalen-1-one 
• 3470-50-6 6-Hydroxy-1-tetralone 
• 847585-90-4 7-(benzyloxy)-4-methyl-1,2-dihydronaphthalene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 847585-84-6 1-{[6-(2,2-dimethyl-3-phenylpropoxy)-1-methyl-3,4-dihydronaphthalen-2-yl]methyl}azetidine-3-carboxylic acid hydrochloride 
• 847585-93-7 6-[3-(4-fluorophenyl)propoxy]-1-methyl-3,4-dihydronaphthalene-2-carboaldehyde 
• 1355088-68-4 C₂₁H₂₁FO₂ 
• 1355088-70-8 C₂₁H₂₁FO₂ 
• 1355088-72-0 C₂₂H₂₄O₂ 
• 1355088-74-2 C₂₂H₂₄O₂ 
• 1355088-76-4 C₂₂H₂₄O₂ 
• 1355088-77-5 C₂₃H₂₆O₂ 
• 872710-02-6 6-{[(2R)-3-(4-fluorophenyl)-2-methylpropyl]oxy}-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde 
• 872709-90-5 6-{[(2S)-3-(4-fluorophenyl)-2-methylpropyl]oxy}-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde 
• 1355088-80-0 C₂₃H₂₅FO₂ 
• 1355088-82-2 C₂₄H₂₇FO₂ 
• 872709-83-6 6-{[(2S)-3-(4-chlorophenyl)-2-methylpropyl]oxy}-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde 
• 847736-94-1 C₂₅H₂₈FNO₃ 

Relevant articles and documents

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本發明之課題係提供一種將S1P5受體作動活性相對於S1P1受體作動活性之平衡經改善的化合物作為有效成份的醫藥組成物，以及將該醫藥組成物用於S1P5媒介疾病(例如，神經退化性疾病、多系統萎縮症、巴金森氏病)等之預防及/或治療的醫藥。 包含通式(V)(式中，各基的定義如說明書所載)所示之化合物或其藥學上可容許之鹽、及藥學上可容許之載體的醫藥組成物，係由於改善了S1P5受體作動活性相對於S1P1受體作動活性的平衡，故作為S1P5媒介疾病之預防及/或治療劑有用。 (式中，所有記號如說明書記載) An object

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A compound shown by general formula (I) (in the formula, all of the symbols are as defined in the specification) has selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skelet

COMPOUND HAVING S1P RECEPTOR BINDING POTENCY AND USE THEREOF

Provided are: a compound represented by formula (I): (wherein ring A and ring D each represent a cyclic group which may have a substituent(s); E and G each represent a bond or a spacer having 1 to 8 atoms in its main chain; L represents a hydrogen atom or a substituent; X represents amino which may have a substituent(s), or a heterocylcic group which contains at least one nitrogen atom and which may have a substituent(s); n represents 0 to 3, in which when n is 2 or more, a plurality of ring A's may be the same or different from one another); a salt thereof; an N-oxide form thereof; a solvate thereof; a prodrug thereof; and a medicament which includes those. The compound represented by formula (I) is capable of binding S1P receptors (in particular, EDG-1 and/or EDG-6), and useful for preventing and/or treating rejection in transplantation, autoimmune diseases, allergic diseases, etc.