848-75-9 Usage
Chemical Properties
Pale Green Solid
Originator
Loramet ,Wyeth, W. Germany,1980
Uses
An analog of Lorazepam (L469850). Sedative, hypnotic.
Controlled substance (depressant).
Manufacturing Process
To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C.
Clinical Use
#N/A
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: metabolism possibly increased by
rifampicin.
Antipsychotics: increased sedative effects; risk of
serious adverse effects in combination with clozapine.
Antivirals: concentration possibly increased by
ritonavir.
Disulfiram: metabolism inhibited, increased sedative
effects.
Sodium oxybate: enhanced effect - avoid.
Metabolism
Lormetazepam is metabolised in the liver to the inactive
glucuronide, and excreted in the urine.
Check Digit Verification of cas no
The CAS Registry Mumber 848-75-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,4 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 848-75:
(5*8)+(4*4)+(3*8)+(2*7)+(1*5)=99
99 % 10 = 9
So 848-75-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3
848-75-9Relevant articles and documents
Crystal form of lormetazepam and preparation method thereof
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Paragraph 0024; 0025; 0026; 0027, (2016/10/24)
The invention relates to lormetazepam, in particular to a crystal form of lormetazepam and a preparation method thereof. The reflecting angle 2theta in the X-ray powder diffraction pattern of the crystal form of lormetazepam has characteristic peaks at 12.20 degrees, 14.69 degrees, 14.77 degrees, 18.43 degrees, 18.55 degrees, 20.85 degrees, 21.19 degrees, 24.43 degrees and 28.32 degrees. The preparation method comprises the steps of: adding a solvent into a lormetazepam crude product, heating up till backflow, after full dissolution of the crude product, continuing heat-insulated backflow, filtering after backflow is finished, cooling and carrying out heat-insulated crystallization on the filtrate, then filtering, and drying the filter cake to a constant weight to obtain the crystal form of lormetazepam. The preparation method disclosed by the invention is simple in operation and easy in realization.