5621-86-3

Basic information

• Product Name: 2',5-dichloro-2-(methylamino)benzophenone
• Synonyms: 2',5-dichloro-2-(methylamino)benzophenone;[5-Chloro-2-(methylamino)phenyl](2-chlorophenyl) ketone;[5-chloro-2-(methylamino)phenyl]-(2-chlorophenyl)methanone;(Methanone, [5-chloro-2-(methylamino)phenyl](2-chlorophenyl)-)
• CAS NO: 5621-86-3
• Molecular Formula: C14H11Cl2NO
• Molecular Weight: 280.14924
• EINECS: 227-050-8
• Mol File: 5621-86-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 450.8°Cat760mmHg
• Flash Point: 226.4°C
• Appearance: /
• Density: 1.328g/cm³
• CAS DataBase Reference: 2',5-dichloro-2-(methylamino)benzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',5-dichloro-2-(methylamino)benzophenone(5621-86-3)
• EPA Substance Registry System: 2',5-dichloro-2-(methylamino)benzophenone(5621-86-3)

Safety Data

• Hazardous Substances Data: 5621-86-3(Hazardous Substances Data)

Usage

General Description

2',5-dichloro-2-(methylamino)benzophenone is a chemical compound that is commonly used in the production of sunscreens and other personal care products. It is an aromatic ketone that belongs to the benzophenone family of compounds. This chemical is known for its ability to absorb ultraviolet (UV) radiation, making it a popular ingredient in sunscreen and sunblock formulas. It works by absorbing UV rays and converting them into less harmful forms of energy, thus protecting the skin from sun damage. However, there has been some concern about the potential health risks associated with 2',5-dichloro-2-(methylamino)benzophenone, as studies have found that it can be absorbed by the skin and may have harmful effects on human health. As a result, there have been efforts to find alternative sun protection ingredients that are safer for human use.

Upstream product

• 16029-98-4 trimethylsilyl iodide 
• 94341-58-9 C₁₄H₁₀Cl₂NO⁽¹⁺⁾*CH₃O₄S^(1-) 
• 77-78-1 dimethyl sulfate 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 74-88-4 methyl iodide 
• 848-75-9 lormetazepam 

Downstream Products

• 59180-18-6 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(phthalylglycyl)glycinanilide 
• 74601-56-2 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide 
• 76337-82-1 ((S)-1-{[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-ethyl)-carbamic acid benzyl ester 
• 59180-29-9 2-methylamino-5,2'-dichlorobenzhydrol 
• 59180-42-6 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide 
• 59180-43-7 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(iodoacetyl)glycinanilide 
• 59180-41-5 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycinanilide hydrobromide 
• 65808-75-5 N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-cyano-acetamide 
• 59179-95-2 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycylglycinanilide 
• 59179-98-5 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide 
• 59180-33-5 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-(phthalylglycyl)glycinanilide 
• 59180-30-2 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide 
• 74088-38-3 (1-{[({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester 
• 59180-32-4 ((S)-1-{[({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester 

Relevant articles and documents

Transition-Metal-Free Synthesis of Acridones via Base-Mediated Intramolecular Oxidative C?H Amination

Intramolecular oxidative C?H amination of 2-aminobenzophenones was achieved in the presence of potassium tert-butoxide and dimethyl sulfoxide. A series of functionalized acridones were prepared in moderate to excellent yields in a mild, efficient, and transition-metal-free manner. (Figure presented.).

A Convenient Preparation of Alkylaminobenzophenones from 2,1-Benzisoxazolium Salts and Iodotrimethylsilane

2-Alkylaminobenzophenones (2) have been prepared in good yields from 2,1-benzisoxazolium salts (1) and iodotrimethylsilane.

Specific Phase-Transfer Catalyzed N-Monoalkylation of 2-Aminobenzophenones

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