59180-29-9

Basic information

• Product Name: Benzenemethanol, 5-chloro-a-(2-chlorophenyl)-2-(methylamino)-
• CAS NO: 59180-29-9
• Molecular Formula: C14H13Cl2NO
• Molecular Weight: 282.169
• Mol File: 59180-29-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 5-chloro-a-(2-chlorophenyl)-2-(methylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 5-chloro-a-(2-chlorophenyl)-2-(methylamino)-(59180-29-9)
• EPA Substance Registry System: Benzenemethanol, 5-chloro-a-(2-chlorophenyl)-2-(methylamino)-(59180-29-9)

Safety Data

• Hazardous Substances Data: 59180-29-9(Hazardous Substances Data)

Usage

Drug class

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Main use

Antidepressant medication

Mechanism of action

Increases levels of serotonin and norepinephrine in the brain

Effects

Improves mood, reduces anxiety, alleviates symptoms of depression

Other uses

Treats panic disorder, social anxiety disorder, generalized anxiety disorder

Administration

Orally, typically in extended-release capsule or tablet form

Side effects

Nausea, dizziness, insomnia

Caution

Should be used carefully in individuals with history of suicidal thoughts or behaviors, bipolar disorder, liver disease.

Upstream product

• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 74067-45-1 2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol 
• 736152-57-1 2-acetyl(methyl)amino-5-chloro-α-(2-chlorophenyl)benzyl acetate 
• 5621-86-3 2',5-dichloro-2-methylaminobenzophenone 
• 736151-00-1 2-acetylamino-5-chloro-α-(2-chlorophenyl)benzyl acetate 

Downstream Products

• 65808-66-4 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-acetylglycinanilide 
• 65022-20-0 2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-methyl-butyramide 
• 59179-98-5 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide 
• 59180-18-6 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(phthalylglycyl)glycinanilide 
• 152906-43-9 (E)-3-({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-acrylic acid ethyl ester 
• 59180-33-5 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-(phthalylglycyl)glycinanilide 
• 74088-38-3 (1-{[({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester 
• 59180-32-4 ((S)-1-{[({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester 
• 76337-78-5 4-chloro-2-(o-chloro-2-hydroxybenzyl)-N-methyl-N^α-acetylglycinanilide 
• 59180-30-2 4-chloro-2-(o-chloro-α-hydroxybenzyl)-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide 

Relevant articles and documents

Novel 4,1-benzoxazepine derivatives with potent squalene synthase inhibitory activities

A series of (3,5-trans)-2-oxo-5-phenyl-1,2,3,5-tetrahydro-4,1-benzoxazepine derivatives were synthesized and evaluated for squalene synthase inhibitory and cholesterol biosynthesis inhibitory activities. Through modification of substituents of the lead compounds 1a and 1b, it was found that 4,1-benzoxazepine-3-acetic acid derivatives with isobutyl and neopentyl groups at the 1-position, the chloro atom at the 7-position, and the chloro and methoxy groups at the 2'-position on the 5-phenyl ring, had potent squalene synthase inhibitory activity. Among such compounds, the 5-(2,3-dimethoxyphenyl) derivative 2t exhibited potent inhibition of cholesterol biosynthesis in HepG2 cells. As a result of optical resolution study of 2t, the absolute stereochemistry required for inibitory activity was determined to be 3R,5S. In vivo study showed that the sodium salt of (3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-aceitc acid 20 effectively reduced plasma cholesterol in marmosets. Copyright

Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzodiazepines

A series of novel peptidoaminobenzophenones has been prepared via several routes and was evaluated for CNS activity. The structure-activity relationships in the series are discussed. In general, dipeptido-N-methylaminobenzophenones showed higher activities than the corresponding NH derivatives. Some compounds had very high activities in antipentylenetetrazole and antifighting tests in mice when orally administered. Very weak toxicity was also found in these compounds. Water solubility of the peptidoaminobenzophenones and their salts were tested. Possible in vivo conversion of peptidoaminobenzophenone by enzymatic cleavage of the terminal amino acid, followed by chemical cyclization to 1,4-benzodiazepine, is also discussed. Such novel open-ring derivatives of 1,4-benzodiazepine may serve as useful CNS agents.