74088-38-3

Basic information

• Product Name: (1-{[({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester
• CAS NO: 74088-38-3
• Molecular Weight: 572.488
• Mol File: 74088-38-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1-{[({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1-{[({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester(74088-38-3)
• EPA Substance Registry System: (1-{[({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-methyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester(74088-38-3)

Safety Data

• Hazardous Substances Data: 74088-38-3(Hazardous Substances Data)

Upstream product

• 5621-86-3 2',5-dichloro-2-methylaminobenzophenone 
• 59180-29-9 2-methylamino-5,2'-dichlorobenzhydrol 
• 74088-26-9 N-(N-benzyloxycarbonyl-DL-valyl)-glycine 

Downstream Products

• 65022-20-0 2-Amino-N-({[4-chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-3-methyl-butyramide 

Relevant articles and documents

Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzodiazepines

A series of novel peptidoaminobenzophenones has been prepared via several routes and was evaluated for CNS activity. The structure-activity relationships in the series are discussed. In general, dipeptido-N-methylaminobenzophenones showed higher activities than the corresponding NH derivatives. Some compounds had very high activities in antipentylenetetrazole and antifighting tests in mice when orally administered. Very weak toxicity was also found in these compounds. Water solubility of the peptidoaminobenzophenones and their salts were tested. Possible in vivo conversion of peptidoaminobenzophenone by enzymatic cleavage of the terminal amino acid, followed by chemical cyclization to 1,4-benzodiazepine, is also discussed. Such novel open-ring derivatives of 1,4-benzodiazepine may serve as useful CNS agents.