849675-46-3Relevant articles and documents
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor
Smolinski, Michael P.,Urgaonkar, Sameer,Pitzonka, Laura,Cutler, Murray,Lee, GwanSun,Suh, Kwee Hyun,Lau, Johnson Y. N.
, p. 3677 - 3693 (2021)
Many chemotherapeutics, such as paclitaxel, are administered intravenously as they suffer from poor oral bioavailability, partly because of efflux mechanism of P-glycoprotein in the intestinal epithelium. To date, no drug has been approved by the U.S. Foo
METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME
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, (2013/02/28)
According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shor