849675-66-7

Basic information

• Product Name: HM 30181A
• Synonyms: HM 30181A;HM30181
• CAS NO: 849675-66-7
• Molecular Weight: 688.74
• Mol File: 849675-66-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: HM 30181A(CAS DataBase Reference)
• NIST Chemistry Reference: HM 30181A(849675-66-7)
• EPA Substance Registry System: HM 30181A(849675-66-7)

Safety Data

• Hazardous Substances Data: 849675-66-7(Hazardous Substances Data)

Usage

General Description

HM 30181A (also known as APD334 or Ozanimod) is a chemical compound known for its medicinal use as a sphingosine 1-phosphate (S1P) receptor modulator. It is used to treat multiple sclerosis and ulcerative colitis due to its effectiveness in reducing lymphocyte (white blood cell) levels in the blood, which can prevent inflammation. Additionally, HM 30181A has potential use in treating other autoimmune diseases. It is typically targeted to S1P1 and S1P5 subtypes.

Upstream product

• 488-93-7 3-Furoic acid 
• 849675-46-3 2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyaniline 
• 4940-39-0 acide chromone carboxylique-2 
• 5112-47-0 4-oxo-4H-chromene-2-carbonyl chloride 
• 2328-12-3 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride 
• 1314518-45-0 S-(benzo[d]thiazol-2-yl) 4-oxo-4H-chromene-2-carbothioate 
• 20357-25-9 6-nitroveratraldehyde 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 82925-02-8 4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine 
• 82925-01-7 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[2-(4-nitrophenyl)ethyl]-isoquinoline 

Relevant articles and documents

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor

Many chemotherapeutics, such as paclitaxel, are administered intravenously as they suffer from poor oral bioavailability, partly because of efflux mechanism of P-glycoprotein in the intestinal epithelium. To date, no drug has been approved by the U.S. Foo

SOLID STATE FORMS OF N-[2-(2-{4-[2-(6,7-DIMETHOXY-3,4-DIHYDRO-2(LH)- ISOQUINOLINYL)ETHYL] PHENYL }-2H-TETRAZOL-5-YL)-4,5-DIMETHOXYPHENYL] -4- OXO-4H-CHROMENE-2-CARBOXAMIDE AND OF ITS MESYLATE SALT

The present disclosure relates to solid state forms of Encequidar (previously referred to as HM-30181A) base, Encequidar ((HM-30181A) mesylate, co-crystals of Encequidar (HM-30181A) mesylate, processes for preparation thereof, as well as pharmaceutical compositions including the same.

METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME

According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shor