84969-25-5

Basic information

• Product Name: 4-Keto-1-[(phenylmethoxy)carbonyl]-L-proline benzyl ester
• Synonyms: 4-Keto-1-[(phenylmethoxy)carbonyl]-L-proline benzyl ester
• CAS NO: 84969-25-5
• Molecular Weight: 353.375
• Mol File: 84969-25-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-Keto-1-[(phenylmethoxy)carbonyl]-L-proline benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Keto-1-[(phenylmethoxy)carbonyl]-L-proline benzyl ester(84969-25-5)
• EPA Substance Registry System: 4-Keto-1-[(phenylmethoxy)carbonyl]-L-proline benzyl ester(84969-25-5)

Safety Data

• Hazardous Substances Data: 84969-25-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 64187-47-9 1-benzyloxycarbonyl-4-keto-L-proline 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 501-53-1 benzyl chloroformate 
• 13500-53-3 N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester 

Downstream Products

• 903518-05-8 (2S)-4-cyanomethyl-2,5-dihydropyrrole-1,2-dicarboxylic acid dibenzyl ester 
• 903518-07-0 (2S,4S)-4-(2-tert-butoxycarbonylaminoethyl)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester 
• 119595-96-9 (2S,4R)-4-(cyanomethyl)proline 
• 119595-95-8 (2S,4S)-4-(cyanomethyl)proline 
• 1316105-42-6 C₂₄H₂₆N₂O₄ 
• 903518-04-7 (2S)-4-cyanomethylenepyrrolidine-1,2-dicarboxylic acid dibenzyl ester 

Relevant articles and documents

Preparation method of intermediate

The invention relates to a preparation method of an intermediate, and belongs to the field of medicinal chemistry. The preparation method comprises at least one reaction step of an addition elimination reaction, a cyclization reaction, a reduction reaction, a decarboxylation reaction and a hydrogenation reaction. According to the method disclosed by the invention, the target intermediate with a single configuration can be simply and conveniently obtained, chiral resolution is effectively avoided, the yield is improved, the cost is reduced, and industrial production is facilitated.

Synthesis of conformationally constrained lysine analogues

The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.

Method for the preparation of N-substituted 4-ketoproline derivatives

Method for the preparation of N-protected 4-ketoproline derivatives of formula I STR1 by oxidation of the corresponding N-protected 4-hydroxyproline derivatives of STR2 using the system TEMPO (2,2,6,6-tetramethylpiperidinyl oxy free radical)/NaOCl.