903518-04-7

Basic information

• Product Name: (2S)-4-cyanomethylenepyrrolidine-1,2-dicarboxylic acid dibenzyl ester
• Synonyms: (2S)-4-cyanomethylenepyrrolidine-1,2-dicarboxylic acid dibenzyl ester
• CAS NO: 903518-04-7
• Molecular Weight: 376.412
• Mol File: 903518-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-4-cyanomethylenepyrrolidine-1,2-dicarboxylic acid dibenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-4-cyanomethylenepyrrolidine-1,2-dicarboxylic acid dibenzyl ester(903518-04-7)
• EPA Substance Registry System: (2S)-4-cyanomethylenepyrrolidine-1,2-dicarboxylic acid dibenzyl ester(903518-04-7)

Safety Data

• Hazardous Substances Data: 903518-04-7(Hazardous Substances Data)

Upstream product

• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 501-53-1 benzyl chloroformate 
• 13500-53-3 N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 84969-25-5 4-Keto-1-[(phenylmethoxy)carbonyl]-L-proline benzyl ester 

Downstream Products

• 119595-96-9 (2S,4R)-4-(cyanomethyl)proline 
• 903518-07-0 (2S,4S)-4-(2-tert-butoxycarbonylaminoethyl)pyrrolidine-1,2-dicarboxylic acid dibenzyl ester 
• 119595-95-8 (2S,4S)-4-(cyanomethyl)proline 
• 903518-05-8 (2S)-4-cyanomethyl-2,5-dihydropyrrole-1,2-dicarboxylic acid dibenzyl ester 

Relevant articles and documents

Synthesis of conformationally constrained lysine analogues

The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.