849773-58-6Relevant articles and documents
N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP
Rossello, Armando,Nuti, Elisa,Carelli, Paolo,Orlandini, Elisabetta,Macchia, Marco,Nencetti, Susanna,Zandomeneghi, Maurizio,Balzano, Federica,Barretta, Gloria Uccello,Albini, Adriana,Benelli, Roberto,Cercignani, Giovanni,Murphy, Gillian,Balsamo, Aldo
, p. 1321 - 1326 (2007/10/03)
Structural manipulation of the pharmacophoric model of type A selective MMP inhibitors (MMPi), obtained by the insertion of some alkyl substituents R 2 possessing an appropriate geometry, steric bulkiness and lipophilicity, is able to improve p