85-29-0Relevant articles and documents
Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes
Huang, Zheng,Liu, Guixia,Qian, Lu,Tang, Xixia,Wang, Yulei
supporting information, (2022/02/23)
The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.
Method for synthesizing biaryl ketone compounds through carbonylation by taking chloroform as carbonyl source without transition metal participation
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Paragraph 0077; 0078-0079; 0113, (2018/12/02)
The invention discloses a method for synthesizing biaryl ketone compounds through carbonylation by taking chloroform as a carbonyl source without transition metal participation. The method disclosed by the invention comprises the following steps: carrying out a cross coupling reaction on aryl halides, aromatic boron compounds and chloroform serving as the carbonyl source in an aqueous solution ofsolvent alcohol or alcohol in the presence of alkali, acids and iodides without transition metal participation, thereby obtaining the biaryl ketone compounds. According to the method for preparing thebiaryl ketone compounds through the cross coupling reaction, disclosed by the invention, the most obvious advantage is that no transition metal catalyst is used and the chloroform serves as the carbonyl source; the method has the advantages such as low cost and zero metal residue caused by no need of the transition metal catalyst; the carbonyl source is safe, cheap and easy to treat; the reactioncondition is mild, and the selectivity is high; the substrate source is wide and stable; and the compatibility of functional groups of the substrate is excellent, the application range of the substrate is wide, and under the optimized reaction conditions, the separation yield of the target product reaches 95%.
Chloro-ruthenium complexes with carbonyl and N-(aryl)pyridine-2-aldimines as ancillary ligands. Synthesis, characterization and catalytic application in C-C cross-coupling of arylaldehydes with arylboronic acids
Dey, Bikash Kali,Dutta, Jayita,Drew, Michael G.B.,Bhattacharya, Samaresh
, p. 176 - 184 (2014/01/06)
Reaction of N-(aryl)pyridine-2-aldimines (L-R, R = OCH3, CH 3, H, Cl and NO2) with [Ru(CO)2Cl 2]n in refluxing ethanol affords a group of complexes of type [Ru(L-R)(CO)2Cl2]. In these complexes the diimine ligands (L-R) are coordinated to the metal center as NN-donors forming five-membered chelate rings, the carbonyls are mutually cis and the two chlorides are trans. Crystal structure of [Ru(L-OCH3)(CO) 2Cl2] has been determined. All the complexes show characteristic 1H NMR signals, and in dichloromethane solution they display intense absorptions in the visible and ultraviolet regions. Cyclic voltammetry on the complexes shows an irreversible oxidation of the metal center within 1.15-1.23 V vs SCE, and reduction(s) of the diimine ligand within -0.70 to -0.96 V vs SCE. The [Ru(L-R)(CO)2Cl2] complexes efficiently catalyze cross-coupling of arylaldehydes with arylboronic acids yielding diaryl ketones.
