851194-04-2Relevant articles and documents
A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346
Zarrinmayeh, Hamideh,Tromiczak, Eric,Zimmerman, Dennis M.,Rankl, Nancy,Ho, Ken H.,Dominguez, Esteban,Castano, Ana,Escribano, Ana,Fernandez, Carmen,Jimenez, Alma,Hornback, William J.,Nisenbaum, Eric S.
, p. 5203 - 5206 (2011/11/14)
The synthesis and structure-activity relationship (SAR) of novel and highly potent positive allosteric modulators of AMPA receptors, 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, are described. These studies indicated that higher