851968-99-5Relevant articles and documents
Enantioselective α-benzylation of aldehydes via photoredox organocatalysis
Shih, Hui-Wen,Vander Wal, Mark N.,Grange, Rebecca L.,MacMillan, David W. C.
supporting information; experimental part, p. 13600 - 13603 (2010/11/18)
The first enantioselective aldehyde α-benzylation using electron-deficient aryl and heteroaryl substrates has been accomplished. The productive merger of a chiral imidazolidinone organocatalyst and a commercially available iridium photoredox catalyst in the presence of household fluorescent light directly affords the desired homobenzylic stereogenicity in good to excellent yield and enantioselectivity. The utility of this methodology has been demonstrated via rapid access to an enantioenriched drug target for angiogenesis suppression.
Highly rigid diphosphane ligands with a large dihedral angle based on a chiral spirobifluorene backbone
Cheng, Xu,Zhang, Qi,Xie, Jian-Hua,Wang, Li-Xin,Zhou, Qi-Lin
, p. 1118 - 1121 (2007/10/03)
High and wide: The high rigidity and large dihedral angle of chiral, spirobifluorene-based diphosphane ligands lead to excellent reactivity and enantioselectivity in the ruthenium-catalyzed asymmetric hydrogenation of α,β-unsaturated carboxylic acids (see scheme).
