13048-77-6

Basic information

• Product Name: 2-Propenoic acid, 2-methyl-3-(4-nitrophenyl)-, (E)-
• CAS NO: 13048-77-6
• Molecular Formula: C10H9NO4
• Molecular Weight: 207.186
• Mol File: 13048-77-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-methyl-3-(4-nitrophenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-methyl-3-(4-nitrophenyl)-, (E)-(13048-77-6)
• EPA Substance Registry System: 2-Propenoic acid, 2-methyl-3-(4-nitrophenyl)-, (E)-(13048-77-6)

Safety Data

• Hazardous Substances Data: 13048-77-6(Hazardous Substances Data)

Upstream product

• 516-05-2 methyl-propanedioic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 53618-29-4 (E)-ethyl 2-methyl-3-(4-nitrophenyl)acrylate 
• 123-62-6 propionic acid anhydride 
• 498-23-7 citraconic acid 
• 100-05-0 4-nitrobenzenediazonium chloride 
• 127-09-3 sodium acetate 
• 67-64-1 acetone 
• 994-51-4 tetrakis-propionyloxy-silane 
• 55591-35-0 1,1'-(4-nitro-phenylmethanediyl)-bis-piperidine 
• 13051-14-4 4-chloro-5-methyl-4-(4-nitro-phenyl)-2,4-dihydro-pyrazol-3-one 
• 40277-76-7 methyl (E)-2-methyl-3-(4-nitrophenyl)acrylate 
• 58550-34-8 (E)-2-methyl-3-(4-nitrophenyl)acrylaldehyde 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 38319-08-3 trans-2-Brom-1-p-nitrophenyl-1-propen 
• 851968-99-5 (R)-3-(4-nitrophenyl)-2-methylpropanoic acid 
• 1361029-49-3 (E)-2-methyl-1-(3-methyl-1H-indol-1-yl)-3-(4-nitrophenyl)prop-2-en-1-one 
• 1361029-59-5 2,9-dimethyl-1-(4-nitrophenyl)-3H-pyrrolo[1,2-a]indol-3-one 
• 37542-81-7 (2E)-2-methyl-3-(4-nitrophenyl)prop-2-en-1-ol 
• 5332-96-7 1-(4-nitrophenyl)propan-2-one 
• 40277-76-7 methyl (E)-2-methyl-3-(4-nitrophenyl)acrylate 
• 1393928-32-9 C₁₆H₂₀N₂O₃ 

Relevant articles and documents

Synthesis of Albicidin Derivatives: Assessing the Role of N-terminal Acylation on the Antibacterial Activity

The peptide antibiotic albicidin, which is synthesized by the plant pathogenic bacterium, Xanthomonas albilineans, represents the most prominent member of a new class of antibacterial gyrase inhibitors. It shows remarkable antibacterial activities against Gram-positive and Gram-negative microorganisms. Its unique structure potentially represents a new lead structure for the development of an antibacterial drug. Here we report the synthesis of 14 albicidin derivatives with structural variations at the N-terminus, primarily investigating the effects of variation of cinnamoyl, phenylpropanoyl, and benzoyl residues. Gyrase inhibition in vitro and determination of minimal inhibitory concentrations were assessed in parallel. Activities in a nanomolar range and the importance of N-acylation were demonstrated.

Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation

Inflammation as a host's excessive immune response to stimulation, is involved in the development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthetic work on marine natural product Chrysamide B, it and a series of derivatives were synthesized and evaluated for their anti-inflammatory activity on inhibition of LPS-induced NO production. Then the preliminary structure–activity relationships were conducted. Among them, Chrysamide B is the most potent anti-inflammatory agent with low cytotoxicity and strong inhibition on the production of NO (IC50 = 0.010 μM) and the activity of iNOS (IC50 = 0.082 μM) in LPS-stimulated RAW 264.7 cells. Primary studies suggested that the mechanism of action may be that it interfered the formation of active dimeric iNOS but not affected transcription and translation. Furthermore, its good performance of anti-inflammatory effect on LPS-induced multiple inflammatory cytokines production, carrageenan-induced paw edema, and endotoxin-induced septic mice, was observed. We believe that these findings would provide an idea for the further modification and research of these analogs in the future.

Multifactorial control of iteration events in a modular polyketide assembly line

Freedom and control: First insights into the rare programmed iteration of an individual polyketide synthase (PKS) module were obtained from the analysis and mutation of aureothin (1) synthase. The first ketosynthase (KS) domain primes the PKS, allowing intermediate retrotransfer. Addition of a designated loading module results in a complete loss of iteration. The downstream KS functions as a gatekeeper for correct chain length. Copyright