852631-12-0

Basic information

• Product Name: [4-(4-methoxyphenoxy)phenyl]acetic acid methyl ester
• Synonyms: [4-(4-methoxyphenoxy)phenyl]acetic acid methyl ester
• CAS NO: 852631-12-0
• Molecular Weight: 272.301
• Mol File: 852631-12-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [4-(4-methoxyphenoxy)phenyl]acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-methoxyphenoxy)phenyl]acetic acid methyl ester(852631-12-0)
• EPA Substance Registry System: [4-(4-methoxyphenoxy)phenyl]acetic acid methyl ester(852631-12-0)

Safety Data

• Hazardous Substances Data: 852631-12-0(Hazardous Substances Data)

Upstream product

• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 100-66-3 methoxybenzene 
• 150-76-5 4-methoxy-phenol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 54916-28-8 1-[4-(4-methoxyphenoxy)phenyl]ethanone 
• 94311-50-9 2-[4-(4-methoxyphenoxy)phenyl]-1-morpholin-4-yl-ethanethione 
• 67-56-1 methanol 
• 92549-44-5 [4-(4-methoxyphenoxy)phenyl]acetic acid 

Downstream Products

• 1322668-20-1 2-(4-(4-methoxyphenoxy)phenyl)ethanol 
• 852631-17-5 [4-(4-methoxyphenoxy)phenyl]malonic dimethyl ester 
• 393796-68-4 5-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-5-[4-(4-methoxy-phenoxy)-phenyl]-pyrimidine-2,4,6-trione 
• 852631-26-6 5-bromo-5-[4-(4-methoxyphenoxy)phenyl]pyrimidine-2,4,6-trione 
• 852631-21-1 5-[4-(4-methoxyphenoxy)phenyl]pyrimidine-2,4,6-trione 

Relevant articles and documents

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

Mycobacterium tuberculosis, the causative agent of tuberculosis, relies on thymidylate kinase (MtbTMPK) for the synthesis of thymidine triphosphates and thus also DNA synthesis. Therefore, this enzyme constitutes a potential Achilles heel of the pathogen. Based on a previously reported MtbTMPK 6-aryl-substituted pyridone inhibitor and guided by two co-crystal structures of MtbTMPK with pyridone- and thymine-based inhibitors, we report the synthesis of a series of aryl-shifted cyanopyridone analogues. These compounds generally lacked significant MtbTMPK inhibitory potency, but some analogues did exhibit promising antitubercular activity. Analogue 11i demonstrated a 10-fold increased antitubercular activity (MIC H37Rv, 1.2 μM) compared to literature compound 5. Many analogues with whole-cell antimycobacterial activity were devoid of significant cytotoxicity.

C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinase imaging

Studies have demonstrated a positive correlation between inflammation, metastasis, or atherosclerosis and the unbalanced or culminated expression of matrix metalloproteinases (MMPs). The molecular imaging of locally upregulated MMP activity in vivo is a c