853400-76-7Relevant articles and documents
COMPOSITIONS OF TROFINETIDE
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, (2021/02/12)
This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.
TREATMENT OF AUTISM SPECTRUM DISORDERES USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID
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Page/Page column 29; 32, (2012/08/08)
This invention provides compounds, compositions and methods for treating Autism Spectrum Disorders (ASD) using glycyl-2-methylprolyl-glutamic acid (G-2-MePE) and analogs thereof. Autism Spectrum Disorders include Autism, Autistic Disorder, Asperger Syndro
Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): Synthesis and structure-activity relationships
Alonso De Diego, Sergio A.,Munoz, Pilar,Gonzalez-Muniz, Rosario,Herranz, Rosario,Martin-Martinez, Mercedes,Cenarruzabeitia, Edurne,Frechilla, Diana,Del Rio, Joaquin,Jimeno, M. Luisa,Garcia-Lopez, M. Teresa
, p. 2279 - 2283 (2007/10/03)
A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role