85446-60-2Relevant articles and documents
Reactivity models of 1-N-vinyluracil and synthesis of a new class of potential antiviral agents by the use of 1,3-dipolar cycloaddition reactions
Colacino,De Luca,Liguori,Napoli,Siciliano,Sindona
, p. 743 - 745 (2007/10/03)
By the use of a convergent approach based on 1,3-dipolar cycloaddition reactions between N-protected formylnitrones generated in situ and 1 -N-vinyluracil, a new class of 4′-aza-analogues of 2′,3′ -dideoxynucleosides is synthesized. Competitive reaction for the endocyclic bond of uracil also brings to a new isoxazolidine derivative fused with the pyrimidine nucleus.
Synthesis of aliphatic nucleoside analogues with potential antiviral activity
Colla,Busson,De Clercq,Vanderhaeghe
, p. 569 - 576 (2007/10/02)
The synthesis of a series of double-modified adenosine and 8-aza-adenosine analogues, altered in the 6-position of the base and having the sugar moiety replaced by an acyclic hydroxylated side chain is described. Also, some aliphatic derivatives of 5-iodo- and E-5-(2-bromovinyl)uracil were prepared. Of all these compounds, only 6-hydroxylamino-9-(2,3-dihydroxypropyl)purine displayed some antiviral activity when tested in primary rabbit kidney cell cultures against vesicular stomatitis, vaccinia or herpes simplex virus.
