854765-40-5

Basic information

• Product Name: Methanone, phenyl[4-phenyl-8-(trifluoromethyl)-3-quinolinyl]-
• CAS NO: 854765-40-5
• Molecular Formula: C23H14F3NO
• Molecular Weight: 377.365
• Mol File: 854765-40-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methanone, phenyl[4-phenyl-8-(trifluoromethyl)-3-quinolinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, phenyl[4-phenyl-8-(trifluoromethyl)-3-quinolinyl]-(854765-40-5)
• EPA Substance Registry System: Methanone, phenyl[4-phenyl-8-(trifluoromethyl)-3-quinolinyl]-(854765-40-5)

Safety Data

• Hazardous Substances Data: 854765-40-5(Hazardous Substances Data)

Upstream product

• 31602-11-6 ethyl 4-chloro-8-(trifluoromethyl)quinoline-3-carboxylate 
• 98-80-6 phenylboronic acid 
• 854777-89-2 [4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone 

Relevant articles and documents

One-pot synthesis of heteroaryl and diheteroaryl ketones through palladium-catalyzed 1,2-addition and oxidation

A synthetic method was developed for the preparation of heteroaryl and diheteroaryl ketones from aldehydes and organoboronic acids through a palladium-catalyzed 1,2-addition and oxidation that uses an aryl iodide as the oxidant. This one-pot process shows high tolerance for a broad range of heterocyclic substrates by using 1.0-3.0 mol-% of the catalyst that is formed from allylpalladium chloride dimer and a thioether-imidazolinium chloride. In addition to fine-tuning the catalytic system, the use of a sterically hindered aryl iodide that has a substituent at the ortho position, such as 2-iodotoluene, is important to obtain the desired ketones with heterocyclic moieties in good to excellent yields. The one-pot synthesis of heteroaryl and diheteroaryl ketones was achieved by a palladium-catalyzed 1,2-addition and oxidation. This catalytic process with 1.0-3.0 mol-% catalyst loading tolerates a broad range of heterocyclic substrates to give ketones with heterocyclic moieties in good to excellent yields. Copyright