85650-55-1

Basic information

• Product Name: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
• Synonyms: cis-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate
• CAS NO: 85650-55-1
• Molecular Formula: C₂₁H₂₀ClNO₅
• Molecular Weight: 401.8402
• EINECS: 288-063-2
• Mol File: 85650-55-1.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 563.1°C at 760 mmHg
• Flash Point: 294.4°C
• Vapor Pressure: 1.62E-13mmHg at 25°C
• CAS DataBase Reference: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate(CAS DataBase Reference)
• NIST Chemistry Reference: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate(85650-55-1)
• EPA Substance Registry System: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate(85650-55-1)

Safety Data

• Hazardous Substances Data: 85650-55-1(Hazardous Substances Data)

Upstream product

• 65576-45-6 asenapine 
• 110-16-7 maleic acid 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 106-48-9 4-chloro-phenol 
• 25563-04-6 o-(p-chlorophenoxy)phenylacetic acid 
• 934996-79-9 5-chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino [4,5-c]pyrrole-1-one 
• 912356-09-3 trans-11-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 912356-09-3 cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 1035404-17-1 ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 29074-98-4 2-chlorobenzyl diethylphosphonate 

Downstream Products

• 65621-78-5 asenapine 
• 65621-78-5 asenapine 

Relevant articles and documents

Method for preparing the maleic acid Arab League fills evenly that

The invention discloses a preparation method of high-purity asenapine maleate. The preparation method comprises the following steps: by taking an asenapine free alkali crude product and a asenapine maleate crude product as an initial raw material, reacting the asenapine free alkali crude product with an organic acid to generate salt or carrying out alkalifying dissociation on the asenapine maleate crude product to asenapine free alkali to be reacted with the organic acid to generate salt so as to obtain asenapine para-benzyl benzyl; crystallizing, filtering and carrying out alkalifying dissociation to obtain asenapine free alkali; then reacting the product obtained from the former step with maleic acid to obtain asenapine maleate; and crystallizing and filtering. The preparation method of high purity asenapine maleate is novel in process route, mild in process condition and simple to operate, and an acceptable product with the purity greater than or equal to 99% can be obtained by just one time without repeatedly recrystallizing operations. Meanwhile, the preparation method further improves the reaction yield, lowers the production cost, is suitable for being applied to industrial production on a large scale, and has good practical value and social and economic benefits.

CRYSTAL FORM OF ASENAPINE MALEATE

The present invention relates to a form of Asenapine Maleate with XRPD peaks at about 5.5,12.5,19.0 and 25.3 and to methods for the preparation thereof. Furthermore the invention relates to a reproducible process for the preparation of pure monoclinic form of Asenapine Maleate in crystalline form and to pharmaceutical compositions comprising the pure monoclinic form of asenapine maleate.

COMPRESSED ORAL DOSAGE FORM FOR ASENAPINE MALEATE

The present invention relates to a compressed pharmaceutical dosage form intended for sublingual or buccal administration and capable of being rapidly disintegrated, the compressed pharmaceutical dosage form containing asenapine maleate in a microcrystalline monoclinic form. It further relates to a method of preparing the same and to a container comprising the dosage form.