857651-01-5Relevant articles and documents
Discovery of INCB8761/PF-4136309, a potent, selective, and orally bioavailable CCR2 antagonist
Xue, Chu-Biao,Wang, Anlai,Han, Qi,Zhang, Yingxin,Cao, Ganfeng,Feng, Hao,Huang, Taisheng,Zheng, Changsheng,Xia, Michael,Zhang, Ke,Kong, Lingquan,Glenn, Joseph,Anand, Rajan,Meloni, David,Robinson,Shao, Lixin,Storace, Lou,Li, Mei,Hughes, Robert O.,Devraj, Rajesh,Morton, Philip A.,Rogier, D. Joseph,Covington, Maryanne,Scherle, Peggy,Diamond, Sharon,Emm, Tom,Yeleswaram, Swamy,Contel, Nancy,Vaddi, Kris,Newton, Robert,Hollis, Greg,Metcalf, Brian
, p. 913 - 918 (2012/02/13)
We report the discovery of a new (S)-3-aminopyrrolidine series of CCR2 antagonists. Structure-activity relationship studies on this new series led to the identification of 17 (INCB8761/PF-4136309) that exhibited potent CCR2 antagonistic activity, high sel