858614-91-2Relevant articles and documents
Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors
Kato, Atsushi,Miyauchi, Saori,Kato, Noriko,Nash, Robert J.,Yoshimura, Yuichi,Nakagome, Izumi,Hirono, Shuichi,Takahata, Hiroki,Adachi, Isao
, p. 3558 - 3568 (2011/07/09)
We report the structure-activity relationship of a series of d-, and l-isofagomine and fagomine isomers as glycosidase inhibitors. Our study revealed that a positive charge at the anomeric position of d-isofagomines enhanced the potency toward β-glycosida
A short and concise synthesis of isofagomine, homoisofagomine, and 5′-deoxyisofagomine
Ouchi, Hidekazu,Mihara, Yukiko,Watanabe, Hitomi,Takahata, Hiroki
, p. 7053 - 7056 (2007/10/03)
A short and concise synthesis of isofagomine derivatives via the epoxidation of chiral N-Boc-5-hydroxy-3-piperidene, followed by regioselective epoxide ring opening is described. This constitutes the first reported synthesis of homoisofagomine and the 5′-