858972-16-4

Basic information

• Product Name: ethyl 2-(4-fluoro-3-nitrophenyl)acetate
• Synonyms: ethyl 2-(4-fluoro-3-nitrophenyl)acetate
• CAS NO: 858972-16-4
• Molecular Formula: C₁₀H₁₀FNO₄
• Molecular Weight: 227.1891032
• Mol File: 858972-16-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(4-fluoro-3-nitrophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-fluoro-3-nitrophenyl)acetate(858972-16-4)
• EPA Substance Registry System: ethyl 2-(4-fluoro-3-nitrophenyl)acetate(858972-16-4)

Safety Data

• Hazardous Substances Data: 858972-16-4(Hazardous Substances Data)

Upstream product

• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 405-50-5 p-Fluorophenylacetic acid 
• 64-17-5 ethanol 
• 192508-36-4 2-(4-fluoro-3-nitrophenyl)acetic acid 

Downstream Products

• 858972-17-5 ethyl 2-(3-amino-4-fluorophenyl)acetate 
• 858972-21-1 (3-azido-4-fluorophenyl)methyl diazomethyl ketone 
• 858972-19-7 ethyl (2-azido-4-fluorophenyl)acetate 
• 858972-22-2 (3-azido-4-fluorophenyl)methyl bromomethyl ketone 
• 858972-25-5 8-benzyl-2-(3-azido-4-fluorophenylmethyl)-6-(4-hydroxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one 
• 858972-20-0 2-azido-4-fluorophenylacetic acid 
• 101566-05-6 indolone-6-acetic acid 
• 1455471-53-0 dimethyl 2,2'-(2-amino-1,4-phenylene)diacetate 
• 1455471-51-8 2,2'-(2-nitro-1,4-phenylene)diacetic acid 
• 1205750-57-7 dimethyl 2,2'-(2-nitro-1,4-phenylene)diacetate 
• 1455471-50-7 diethyl 2-(4-(2-ethoxy-2-oxoethyl)-2-nitrophenyl)malonate 

Relevant articles and documents

Preparation method of 3-nitro-4-fluorophenylacetate

The invention discloses a method for preparing 3-nitro-4-fluorophenylacetate by using a microreactor, and belongs to the technical field of organic matter synthesis, the microreactor comprises precooling modules and a mixing module, and the method specifically comprises the following steps: (1) preparing raw materials: preparing a mixed solution of 4-fluorophenylacetate and concentrated sulfuric acid and a nitric acid solution; (2) pre-cooling: cooling the pre-cooling modules and the mixing module to a reaction temperature in advance, and then respectively adding the mixed solution of 4-fluorophenylacetate and concentrated sulfuric acid and the nitric acid solution into different pre-cooling modules; (3) mixing: after the raw materials are pre-cooled, adding the pre-cooled raw materials into the mixing module for mixing reaction; and (4) performing quenching and post-processing. The method provided by the invention can effectively control the heat release problem of the nitration reaction, and is high in safety; and the 3-nitro-4-fluorophenylacetate can be prepared with high selectivity, the conversion rate of the 4-fluorophenylacetate can reach 98.4%, and the selectivity can reach99: 1.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.