860782-82-7

Basic information

• Product Name: 2-benzyloxy-ω-bromo-4-methylacetophenone
• Synonyms: 2-benzyloxy-ω-bromo-4-methylacetophenone
• CAS NO: 860782-82-7
• Molecular Weight: 319.198
• Mol File: 860782-82-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-benzyloxy-ω-bromo-4-methylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyloxy-ω-bromo-4-methylacetophenone(860782-82-7)
• EPA Substance Registry System: 2-benzyloxy-ω-bromo-4-methylacetophenone(860782-82-7)

Safety Data

• Hazardous Substances Data: 860782-82-7(Hazardous Substances Data)

Upstream product

• 58110-89-7 1-[2-(benzyloxy)-4-methylphenyl]ethanone 

Downstream Products

• 860782-83-8 ω-acetoxy-2-benzyloxy-4-methylacetophenone 

Relevant articles and documents

Phytotoxins from Hofmeisteria schaffneri: Isolation and synthesis of 2′-(2″-hydroxy-4″-methylphenyl)-2′-oxoethyl acetate

Activity-directed fractionation of a CH2Cl2-MeOH (1:1) extract of Hofmeisteria schaffneri led to the isolation of a new phytotoxin characterized as 2′-(2″-hydroxy-4″-methylphenyl)- 2′-oxoethyl acetate and designated the trivial name of hofmeisterin (1). In addition, the known compounds β-carotene, euparin, and 3′,4′,4a′,9a′-tetrahydro-6,7′- dimethylspiro[benzofuran-3(2H),2′-pyrano[2,3-b]benzofuran]-2, 4a′-diol (2) were obtained. The identification of the isolates was accomplished by spectroscopic methods. The structure of 1 was unequivocally confirmed by synthesis. The methyl derivative 1a was also synthesized following the same strategy. Compounds 1 and 2 inhibited radicle growth of Amaranthus hypochondriacus (IC50 = 3.2 × 10-4 and 1.2 × 10-5 M, respectively) and significantly inhibited activation of the calmodulin (CaM)-dependent enzyme cAMP phosphodiesterase (PDE) with IC 50 values of 4.4 and 4.22 μM, respectively.