861136-85-8Relevant articles and documents
Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors based on a tetrahydro-1(2H)-isoquinolinone Scaffold: Synthesis, biological evaluation and X-ray crystal structure
Peukert, Stefan,Schwahn, Uwe,Guessregen, Stefan,Schreuder, Herman,Hofmeister, Armin
, p. 1550 - 1554 (2007/10/03)
The synthesis, activity and physical properties of two series of novel potent tetrahydro-1(2H)-isoquinolinone based PARP-1 inhibitors are described. The new structural classes with a non-planar ring system interact specifically with the PARP-1 protein at the nicotinamide-binding site. Georg Thieme Verlag Stuttgart.