7114-80-9

Basic information

• Product Name: 3-METHYLISOQUINOLIN-1(2H)-ONE
• Synonyms: 3-METHYLISOQUINOLIN-1(2H)-ONE;3-Methylisoquinolin-1-ol;3-Methyl-2H-isoquinolin-1-one;1(2H)-Isoquinolinone, 3-methyl-;3-Methyl-1(2H)-isoquinolone;3-Methyl-1-isoquinolone
• CAS NO: 7114-80-9
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Mol File: 7114-80-9.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-METHYLISOQUINOLIN-1(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLISOQUINOLIN-1(2H)-ONE(7114-80-9)
• EPA Substance Registry System: 3-METHYLISOQUINOLIN-1(2H)-ONE(7114-80-9)

Safety Data

• Hazardous Substances Data: 7114-80-9(Hazardous Substances Data)

Usage

General Description

3-METHYLISOQUINOLIN-1(2H)-ONE is a chemical compound with the molecular formula C10H9NO. It is a heterocyclic organic compound that is structurally related to quinoline. This chemical is widely used in the pharmaceutical industry as a precursor for the synthesis of various drugs and bioactive molecules due to its versatile reactivity and potential pharmacological properties. Additionally, 3-METHYLISOQUINOLIN-1(2H)-ONE has also been studied for its potential anti-inflammatory and antioxidant properties, making it a potentially valuable compound for the development of new therapeutic agents. Furthermore, it has shown promise in the field of organic synthesis as a key intermediate in the preparation of complex molecular structures.

Upstream product

• 14548-00-6 3-methylisoquinoline N-oxide 
• 108-24-7 acetic anhydride 
• 29539-21-7 3-methylisocoumarin 
• 52962-26-2 3-(o-carboxyphenyl)pentane-2,4-dione 
• 855623-28-8 4-hydroxy-3-methyl-3,4-dihydro-2H-isoquinolin-1-one 
• 107-05-1 3-chloroprop-1-ene 
• 7115-16-4 1-chloro-3-methyl-isoquinoline 
• 708-14-5 phthalide-3-carboxylic acid 
• 1125-80-0 3-methylisoquinoline 
• 88-65-3 2-bromobenzoic-acid 
• 3759-28-2 (2-cyanophenyl)acetonitrile 
• 2848-28-4 α-Acetylhomophthalic anhydride 
• 2852-91-7 (2-carboxyphenyl)acetone 
• 89-51-0 Homophthalic acid 

Downstream Products

• 7115-16-4 1-chloro-3-methyl-isoquinoline 
• 1125-80-0 3-methylisoquinoline 
• 861136-85-8 1-[3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-ethanone 
• 861136-90-5 [3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-methanol 
• 861136-87-0 (3-methansulfonyl-phenyl)-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-yl)-amine 
• 861136-88-1 N-[3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-acetamide 
• 861136-86-9 3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-N,N-dimethyl-benzamide 
• 861136-89-2 (1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-yl)-(3-trifluoromethoxy-phenyl)-amine 
• 27107-35-3 5-Methyl-s-triazolo<3,4-a>isochinolin 
• 867006-65-3 4-bromo-3-methyl-2H-isoquinolin-1-one 
• 1351515-62-2 ((1-oxo-1,2-dihydroisoquinolin-3-yl)methyl)triphenylphosphonium bromide 
• 1351515-63-3 (E,Z)-N,N-dimethyl-2-(2-(1-oxo-1,2-dihydroisoquinolin-3-yl)vinyl)-4-phenyl-1H-imidazole-1-sulfonamide 
• 1351515-64-4 (E,Z)-3-(2-(4-phenyl-1H-imidazol-2-yl)vinyl)isoquinolin-1(2H)-one 

Relevant articles and documents

Rhodium(III)-Catalyzed C-H Activation: Annulation of Petrochemical Feedstocks for the Construction of Isoquinolone Scaffolds

We describe a simple and robust procedure for the Rh(III)-catalyzed [4+2] cycloaddition of feedstock gases enabled through C-H activation. A diverse set of 3,4-dihydroisoquinolones and 3-methylisoquinolones have been prepared in good to excellent yields.

Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds

Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds provides a simple and atom-economical approach toward enamides and isoquinolones. This paper reports two catalyst systems for these transformations which employ iron(ii) complexes [Fe(dpbz)]Br2 (dpbz = 1,2-bis(diphenylphosphino)benzene) and FeBr2/Et3N, respectively. [Fe(dpbz)]Br2 was found to be highly effective at converting 2-azido-2,3-dihydro-1H-inden-1-ones to isoquinolones. The reagent combination of FeBr2/Et3N, on the other hand, exhibited a broader catalytic scope, owing to the beneficial effect of Et3N. This latter catalyst system enables 2-azido-2-methyl-1,3-dicarbonyl compounds to be converted to the corresponding enamides under mild conditions in good yields.

USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS

The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as antihyperproliferative agents. (I) or (II)