863487-03-0

Basic information

• Product Name: methyl α-acetamido-β-(2-bromophenyl)-acrylate
• Synonyms: methyl α-acetamido-β-(2-bromophenyl)-acrylate
• CAS NO: 863487-03-0
• Molecular Weight: 298.136
• Mol File: 863487-03-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl α-acetamido-β-(2-bromophenyl)-acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl α-acetamido-β-(2-bromophenyl)-acrylate(863487-03-0)
• EPA Substance Registry System: methyl α-acetamido-β-(2-bromophenyl)-acrylate(863487-03-0)

Safety Data

• Hazardous Substances Data: 863487-03-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 6630-33-7 ortho-bromobenzaldehyde 
• 543-24-8 N-acetylglycine 
• 461706-35-4 (Z)-4-(2-bromobenzylidene)-2-methyloxazol-5(4H)-one 
• 461706-35-4 4-(2-bromophenyl)methylene-2-methyl-5(4H)-oxazolone 
• 124-41-4 sodium methylate 
• 5429-56-1 N-Acetamidoacrylic acid 
• 583-55-1 1-Bromo-2-iodobenzene 
• 35356-70-8 Methyl 2-acetamidoacrylate 

Downstream Products

• 164461-16-9 methyl (R)-2-acetamido-3-(2-bromophenyl)propanoate 
• 194724-02-2 (S)-methyl 2-acetamido-3-(2-bromophenyl)propanoate 
• 110592-39-7 (S)-N-acetyl-2,3-dihydroindoline-2-carboxylic acid methyl ester 

Relevant articles and documents

Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis. This journal is

Silver-Promoted Direct Phosphorylation of Bulky C(sp2)-H Bond to Build Fully Substituted β-Phosphonodehydroamino Acids

A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted α,β-dehydro α-amino carboxylic esters and H-phosphites is described. This C(sp2)-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted β-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.

Cation-triggered switchable asymmetric catalysis with chiral aza-crownphos

An aza-crown ether, modified phosphoramidite ligand, has been designed and synthesized. The ON/OFF reversible switch of catalytic activity for its rhodium catalyst was thoroughly investigated in the asymmetric hydrogenation of dehydroamino acid esters modulated by host-guest interactions. In the OFF state, the catalyst is almost inactive (less than 1% conversion) because of the formation of an intermolecular sandwich complex by two aza-crown ether moities and the cationic rhodium metal center. In using alkali-metal-cations as the trigger, the catalytic activity was turned ON and consequently resulted in full conversions and excellent enantioselectivities (up to 98% ee).