863578-50-1

Basic information

• Product Name: METHYL 3-CYCLOHEXYL-2-(2-HYDROXYPHENYL)-1H-INDOLE-6-CARBOXYLATE
• Synonyms: METHYL 3-CYCLOHEXYL-2-(2-HYDROXYPHENYL)-1H-INDOLE-6-CARBOXYLATE;1H-Indole-6-carboxylic acid, 3-cyclohexyl-2-(2-hydroxyphenyl)-, methyl ester
• CAS NO: 863578-50-1
• Molecular Formula: C₂₂H₂₃NO₃
• Molecular Weight: 349.42
• Mol File: 863578-50-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 547.668°C at 760 mmHg
• Flash Point: 285.019°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 3-CYCLOHEXYL-2-(2-HYDROXYPHENYL)-1H-INDOLE-6-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-CYCLOHEXYL-2-(2-HYDROXYPHENYL)-1H-INDOLE-6-CARBOXYLATE(863578-50-1)
• EPA Substance Registry System: METHYL 3-CYCLOHEXYL-2-(2-HYDROXYPHENYL)-1H-INDOLE-6-CARBOXYLATE(863578-50-1)

Safety Data

• Hazardous Substances Data: 863578-50-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1H-indole-6-carboxylate is a chemical compound with the molecular formula C23H25NO3. It is a derivative of indole, a heterocyclic organic compound. This chemical is a carboxylate ester, containing a methyl ester and a hydroxyphenyl group. It has potential applications in pharmaceuticals and organic synthesis. The compound may have biological activities or pharmacological properties, although further research is needed to fully understand its potential uses.

InChI:InChI=1/C22H23NO3/c1-26-22(25)15-11-12-16-18(13-15)23-21(17-9-5-6-10-19(17)24)20(16)14-7-3-2-4-8-14/h5-6,9-14,23-24H,2-4,7-8H2,1H3

Upstream product

• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 89466-08-0 2-hydroxyphenyl boronic acid 
• 269409-97-4 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 1414926-65-0 2-cyclohexyl-1-(2-hydroxyphenyl)ethan-1-one 
• 1414926-66-1 methyl 4-(2-(2-cyclohexylacetyl)phenoxy)-3-nitrobenzoate 
• 1414926-67-2 4-[1-cyclohexyl-2-(2-hydroxy-phenyl)-2-oxo-ethyl]-3-nitrobenzoic acid methyl ester 
• 134560-43-3 2-cyclohexyl-N-methoxy-N-methylacetamide 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 108-94-1 cyclohexanone 
• 5292-21-7 Cyclohexylacetic acid 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 578-57-4 2-bromoanisole 
• 1281318-51-1 2-cyclohexyl-1-(2-methoxyphenyl)ethan-1-one 

Downstream Products

• 863578-83-0 2-[2-(2-chloroethoxy)phenyl]-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester 
• 863578-55-6 11-cyclohexyl-5-oxa-6a-azabenzo[a]fluorene-8-carboxylic acid methyl ester 
• 1208129-98-9 methyl 2-[2-(benzyloxy)phenyl]-3-cyclohexyl-1H-indole-6-carboxylate 
• 863578-84-1 12-cyclohexyl-6,7-dihydro-5-oxa-7a-azadibenzo[a,e]azulene-9-carboxylic acid methyl ester 
• 1026628-46-5 14-cyclohexyl-7,8-dihydro-6H-indole[1,2-e][1,5]benzoxazocine-11-carboxylic acid methyl ester 
• 886041-53-8 3-cyclohexyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}-1H-indole-6-carboxylic acid methyl ester 
• 1104194-47-9 methyl 2-[2-(allyloxy)phenyl]-3-cyclohexyl-1H-indole-6-carboxylate 
• 886042-33-7 methyl 14-cyclohexyl-7-methylene-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate 
• 956580-04-4 methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate 
• 1104195-22-3 methyl 2-(2-{[(2S)-4-azido-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)butyl]oxy}-3-methoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylate 

Relevant articles and documents

An efficient process for the large-scale synthesis of a 2,3,6-trisubstituted indole

The efficient synthesis of a key trisubstituted indole intermediate 1 is described. The synthetic route required the use of an aryl Grignard reagent which was not commercially available, and the large-scale formation of this fragment and the thermal evalu

Discovery of (7 R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral genome and has been a prime target for drug discovery eff

Inhibitors of HCV replication

Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.