886041-53-8

Basic information

• Product Name: 3-cyclohexyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}-1H-indole-6-carboxylic acid methyl ester
• Synonyms: 3-cyclohexyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}-1H-indole-6-carboxylic acid methyl ester
• CAS NO: 886041-53-8
• Molecular Weight: 405.494
• Mol File: 886041-53-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-cyclohexyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}-1H-indole-6-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclohexyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}-1H-indole-6-carboxylic acid methyl ester(886041-53-8)
• EPA Substance Registry System: 3-cyclohexyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}-1H-indole-6-carboxylic acid methyl ester(886041-53-8)

Safety Data

• Hazardous Substances Data: 886041-53-8(Hazardous Substances Data)

Upstream product

• 863578-50-1 3-cyclohexyl-2-(2-hydroxy-phenyl)-1H-indole-6-carboxylic acid methyl ester 
• 70987-78-9 (S)-Glycidyl tosylate 
• 118712-60-0 S-oxiran-2-ylmethyl 4-nitrobenzenesulfonate 
• 89466-08-0 2-hydroxyphenyl boronic acid 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 

Downstream Products

• 886041-81-2 methyl 14-cyclohexyl-7-[methyl(2-pyrrolidin-1-ylethyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate 
• 886041-56-1 methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate 
• 886041-73-2 methyl 14-cyclohexyl-7-(4-methylpiperazin-1-yl)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate 
• 886041-59-4 methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate 
• 886041-80-1 methyl 14-cyclohexyl-7-[(2-pyrrolidin-1-ylethyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate 

Relevant articles and documents

Mitsunobu inversion of a secondary alcohol with diphenylphosphoryl azide. application to the enantioselective multikilogram synthesis of a HCV polymerase inhibitor

The development of a practical synthesis of the hepatitis C virus polymerase inhibitor 1 was necessary to support preclinical safety and human clinical studies. Significant challenges face the process chemist in developing a route to 1 that is amenable to

Discovery of (7 R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral genome and has been a prime target for drug discovery eff